{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T02:41:58Z","timestamp":1778812918253,"version":"3.51.4"},"reference-count":34,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,8,13]],"date-time":"2013-08-13T00:00:00Z","timestamp":1376352000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Sande\/Pfizer Fellowship Award in International Infectious Diseases"},{"name":"Healthcare Research and Quality","award":["T32 HS000066"],"award-info":[{"award-number":["T32 HS000066"]}]},{"name":"National Institute for Allergy and Infectious Diseases and CTSC","award":["T32 AI007613"],"award-info":[{"award-number":["T32 AI007613"]}]},{"name":"National Institute for Allergy and Infectious Diseases and CTSC","award":["UL1-RR024996"],"award-info":[{"award-number":["UL1-RR024996"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We explored response to single\u2010dose praziquantel therapy in a cohort of 33 women with <jats:italic><jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>chistosoma haematobium<\/jats:italic> infection in rural <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>wanza, <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>anzania. Women with <jats:italic><jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>.\u00a0haematobium<\/jats:italic> infection confirmed both by eggs in urine and by polymerase chain reaction (<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>) received single\u2010dose praziquantel and treatment of concomitant sexually transmitted infections. Macroscopic cervical abnormalities were also quantified. After 6\u00a0months, microscopically detectable egg excretion was eliminated, but 8 of 33 women (24%) were persistently positive for <jats:italic><jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>.\u00a0haematobium<\/jats:italic> by <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>, and 11 (33%) had cervical abnormalities potentially attributable to schistosomiasis. This suggests that praziquantel treatment more frequently than every 6\u00a0months may be necessary for complete elimination of the parasite and prevention of genital tissue pathology. This aggressive therapy may in turn play a key role decreasing <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> susceptibility in millions of people living in regions in which <jats:italic><jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>.\u00a0haematobium<\/jats:italic> is endemic.<\/jats:p>","DOI":"10.1111\/tmi.12154","type":"journal-article","created":{"date-parts":[[2013,8,13]],"date-time":"2013-08-13T04:54:34Z","timestamp":1376369674000},"page":"1090-1096","source":"Crossref","is-referenced-by-count":43,"title":["Detectable urogenital schistosome <scp>DNA<\/scp> and cervical abnormalities 6\u00a0months after single\u2010dose praziquantel in women with <i><scp>S<\/scp>chistosoma haematobium<\/i> infection"],"prefix":"10.1111","volume":"18","author":[{"given":"Jennifer A.","family":"Downs","sequence":"first","affiliation":[{"name":"Department of Medicine Weill Cornell Medical College New York NY USA"},{"name":"Department of Medicine Bugando Medical Centre Mwanza Tanzania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrick","family":"Kabangila","sequence":"additional","affiliation":[{"name":"Department of Medicine Bugando Medical Centre Mwanza Tanzania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaco J.","family":"Verweij","sequence":"additional","affiliation":[{"name":"Department of Parasitology Leiden University Medical Centre Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyasinta","family":"Jaka","sequence":"additional","affiliation":[{"name":"Department of Medicine Bugando Medical Centre Mwanza Tanzania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert N.","family":"Peck","sequence":"additional","affiliation":[{"name":"Department of Medicine Weill Cornell Medical College New York NY USA"},{"name":"Department of Medicine Bugando Medical Centre Mwanza Tanzania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel E.","family":"Kalluvya","sequence":"additional","affiliation":[{"name":"Department of Medicine Bugando Medical Centre Mwanza Tanzania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M.","family":"Changalucha","sequence":"additional","affiliation":[{"name":"National Institute for Medical Research \u2013 Mwanza Research Centre Mwanza Tanzania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Warren D.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Medicine Weill Cornell Medical College New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisette","family":"van Lieshout","sequence":"additional","affiliation":[{"name":"Department of Parasitology Leiden University Medical Centre Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel W.","family":"Fitzgerald","sequence":"additional","affiliation":[{"name":"Department of Medicine Weill Cornell Medical College New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,8,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"crossref","first-page":"342","DOI":"10.4269\/ajtmh.2006.74.342","article-title":"Failure of standard treatment with praziquantel in two returned travelers with Schistosoma haematobium infection","volume":"74","author":"Alonso D","year":"2006","journal-title":"The American Journal of Tropical Medicine and Hygiene"},{"key":"e_1_2_6_3_1","unstructured":"Centers for Disease Control.(2013)Parasites \u2010 Schistosomiasis \u2010 Resources for Health Professionals. Available from:http:\/\/www.cdc.gov\/parasites\/schistosomiasis\/health_professionals\/index.html(accessed 23 May 2013)."},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1994.50.281"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000265"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2011.10-0585"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2012.12-0395"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(75)90027-9"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/095646249400500517"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69440-3"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-706X(96)00027-7"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000430"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.aids.0000210614.45212.0a"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trstmh.2005.09.010"},{"key":"e_1_2_6_15_1","doi-asserted-by":"crossref","first-page":"79","DOI":"10.4269\/ajtmh.2008.79.79","article-title":"Prevention of gynecologic contact bleeding and genital sandy patches by childhood anti\u2010schistosomal treatment","volume":"79","author":"Kjetland EF","year":"2008","journal-title":"The American Journal of Tropical Medicine and Hygiene"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2009.09-0081"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2011.10.008"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-443-06839-3.00289-7"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trstmh.2006.08.008"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.279.15.1211"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1179\/136485908X337490"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-706X(01)00086-9"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2001.65.233"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-706X(00)00125-X"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-706X(96)00030-7"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001270"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(86)80456-7"},{"key":"e_1_2_6_28_1","first-page":"1","article-title":"Food security and development in South Sudan: a call to action","author":"Tappis H","year":"2013","journal-title":"Public Health Nutrition"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.5.1487-1495.2003"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-706X(03)00029-9"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000422"},{"key":"e_1_2_6_32_1","unstructured":"World Health Organization.Preventive chemotherapy in human helminthiasis. (2006) Available from:http:\/\/www.who.int\/neglected_diseases\/preventive_chemotherapy\/pct_manual\/en\/(accessed 22 May 2013)."},{"key":"e_1_2_6_33_1","unstructured":"World Health Organization.Report of an Informal Working Group Meeting on Urogenital Schistosomiasis and HIV Infection. (2010) Available from:http:\/\/whqlibdoc.who.int\/hq\/2010\/WHO_HTM_NTD_PCT_2010.5_eng.pdf(accessed 3 December 2010)."},{"key":"e_1_2_6_34_1","unstructured":"World Health Organization.Schistosomiasis. (2012) Available from:http:\/\/www.who.int\/mediacentre\/factsheets\/fs115\/en\/index.html(accessed 6 February 2013)."},{"key":"e_1_2_6_35_1","unstructured":"World Health Organization.(2013)Schistosomiasis \u2010 strategy. Available from:http:\/\/www.who.int\/schistosomiasis\/strategy\/en\/(accessed 22 May 2013)."}],"container-title":["Tropical Medicine &amp; International Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftmi.12154","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftmi.12154","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tmi.12154","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T13:03:32Z","timestamp":1696165412000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tmi.12154"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8,13]]},"references-count":34,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["10.1111\/tmi.12154"],"URL":"https:\/\/doi.org\/10.1111\/tmi.12154","archive":["Portico"],"relation":{},"ISSN":["1360-2276","1365-3156"],"issn-type":[{"value":"1360-2276","type":"print"},{"value":"1365-3156","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,13]]}}}