{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T09:50:25Z","timestamp":1778925025605,"version":"3.51.4"},"reference-count":21,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2013,9,14]],"date-time":"2013-09-14T00:00:00Z","timestamp":1379116800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2013,11]]},"abstract":"Abstract<\/jats:title>Objective<\/jats:title>To assess the efficacy and side effects of praziquantel in the treatment for S<\/jats:styled-content>chistosoma mansoni<\/jats:italic> infection in school children in S<\/jats:styled-content>enbete Town, northeastern E<\/jats:styled-content>thiopia.<\/jats:p><\/jats:sec>Methods<\/jats:title>A single stool specimen was collected from 342 school children and examined for S<\/jats:styled-content>.\u00a0mansoni<\/jats:italic> ova using K<\/jats:styled-content>ato\u2013K<\/jats:styled-content>atz technique (single slide) and formol\u2010ether concentration technique. Positive individuals were treated with a single oral dose of praziquantel at 40\u00a0mg\/kg body weight. Egg reduction and cure rates were assessed 4\u00a0weeks post\u2010treatment. Structured questionnaires were also used to collect pre\u2010treatment and 24\u2010h post\u2010treatment signs and symptoms to assess side effects of the drug.<\/jats:p><\/jats:sec>Results<\/jats:title>Praziquantel reduced the egg rate by 79.46% and achieved a cure rate of 82.89% 4\u00a0weeks post\u2010treatment. 86.67% of the children presented at least one transient drug\u2010related sign and symptom 24\u2010h post\u2010treatment.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Praziquantel demonstrated sufficient efficacy against S<\/jats:styled-content>.\u00a0mansoni<\/jats:italic> in S<\/jats:styled-content>enbete T<\/jats:styled-content>own, northeastern E<\/jats:styled-content>thiopia. Mild and transient signs and symptoms associated with therapy disappeared within 24\u00a0h without specific treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.12187","type":"journal-article","created":{"date-parts":[[2013,10,8]],"date-time":"2013-10-08T16:52:23Z","timestamp":1381251143000},"page":"1338-1343","source":"Crossref","is-referenced-by-count":15,"title":["Efficacy and side effects of praziquantel in the treatment for S<\/scp>chistosoma mansoni<\/i> infection in school children in S<\/scp>enbete T<\/scp>own, northeastern E<\/scp>thiopia"],"prefix":"10.1111","volume":"18","author":[{"given":"Birehanu","family":"Reta","sequence":"first","affiliation":[{"name":"Gambella National Regional State Health Bureau Gambella Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berhanu","family":"Erko","sequence":"additional","affiliation":[{"name":"Aklilu Lemma Institute of Pathobiology Addis Ababa University Addis Ababa Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,9,14]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"170","article-title":"A short review of some pharmacological, therapeutic and toxicological properties of praziquantel in man and animals","volume":"19","author":"Badreldin H","year":"2006","journal-title":"Pakistan Journal of Pharmaceutical Sciences"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-706X(98)00084-9"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2010.10.019"},{"key":"e_1_2_6_5_1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s00436-002-0751-z","article-title":"Praziquantel","volume":"90","author":"Cioli D","year":"2003","journal-title":"Parasitology Research"},{"key":"e_1_2_6_6_1","first-page":"3","article-title":"Efficacy of Praziquantel in Treating Schistosoma mansoni Infected School Children in Tumuga and Waja, North Ethiopia","volume":"2","author":"Dejene T","year":"2010","journal-title":"Momona Ethiopian Journal of Science"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(89)90332-5"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0035-9203(02)90388-3"},{"key":"e_1_2_6_9_1","first-page":"318","article-title":"Efficacy and side effects of praziquantel treatment in a highly endemic Schistosoma mansoni focus at Lake Albert, Uganda","volume":"69","author":"Kabatereine NB","year":"2003","journal-title":"American Journal of Tropical Medicine and Hygiene"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001321"},{"key":"e_1_2_6_11_1","unstructured":"MontresorA CromptonDW BundyDAP HallA&SavioliL(1998)Guidelines for the evaluation of soil\u2010transmitted helminthiasis and schistosomiasis at community level.World Health Organization Geneva.http:\/\/apps.who.int\/ctd\/intpara\/98_1.pdf"},{"key":"e_1_2_6_12_1","first-page":"28","article-title":"Schistosomiasis: health effects on women","volume":"3","author":"Nawal M","year":"2010","journal-title":"Reviews in Obstetrics & Gynecology"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0035-9203(03)00003-8"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-308X(10)73002-5"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/trstmh\/trt024"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3156.2000.00646.x"},{"key":"e_1_2_6_17_1","article-title":"Praziquantel treatment of school children from single and mixed infection foci of intestinal and urogenital schistosomiasis along the Senegal River Basin: monitoring treatment success and re\u2010infection patterns","author":"Webster BL","journal-title":"Acta Tropica"},{"key":"e_1_2_6_18_1","first-page":"25","volume-title":"Basic Laboratory Methods in Medical Parasitology","author":"WHO","year":"1991"},{"key":"e_1_2_6_19_1","first-page":"1","article-title":"Prevention and control of schistosomiasis and soil\u2010transmitted helminthiasis","volume":"912","author":"WHO","year":"2002","journal-title":"World Health Organization Technical Report Series"},{"key":"e_1_2_6_20_1","unstructured":"WHO(2013a).Schistosomiasis a major public health problem.http:\/\/www.who.int\/schistosomiasis\/en\/. accessed on July 21 2013."},{"key":"e_1_2_6_21_1","unstructured":"WHO(2013b)Assessing the Efficacy of Anthelminthic Drugs Against Schistosomiasis and Soil\u2010Transmitted Helminthiases. 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