{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T14:03:27Z","timestamp":1770818607942,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2013,10,18]],"date-time":"2013-10-18T00:00:00Z","timestamp":1382054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the occurrence of low bone mineral density (<jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content>) and its relationship with clinical and laboratorial characteristics in children and young adults with sickle cell anaemia living in Northeast\u2010Brazil, and to assess the role of radiography in diagnosing low <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Bone mineral density of lumbar spine was measured by dual energy X\u2010ray absorptiometry (<jats:styled-content style=\"fixed-case\">DXA<\/jats:styled-content>) in 27 patients with Sickle cell anaemia (<jats:styled-content style=\"fixed-case\">SCA<\/jats:styled-content>) aged 7\u201328\u00a0years. Clinical history, calcium and calorie intake, laboratory measurements, anthropometrics and pubertal development were assessed, and X\u2010rays were obtained. Z\u2010scores and T\u2010scores for weight, height, Body Mass Index (<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>) and <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content> were calculated using age and gender matched reference data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean lumbar spine <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content> Z\u2010scores and T\u2010scores were \u22121.81 <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> in boys and \u22120.80 <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> in girls. <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content> Z\u2010scores were below \u20102 <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> in 33.3% of girls and in 46.7% of boys. Low <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content> (&lt;\u22122 <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>) occurred significantly more in patients with low height\u2010for\u2010age (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.02), low weight\u2010for\u2010age (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.001) and low <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>\u2010for\u2010age (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.006). No significant relationships were found between <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content> and other clinical and laboratory parameters. Radiography had a sensitivity of 75% and a specificity of 36% to detect low <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content>, and was considered not useful in this context.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with low height and\/or low weight\u2010for\u2010age seem to be at high risk for developing low <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.12211","type":"journal-article","created":{"date-parts":[[2013,10,18]],"date-time":"2013-10-18T11:25:48Z","timestamp":1382095548000},"page":"1539-1546","source":"Crossref","is-referenced-by-count":19,"title":["Bone mineral density, growth, pubertal development and other parameters in Brazilian children and young adults with sickle cell anaemia"],"prefix":"10.1111","volume":"18","author":[{"given":"M.","family":"Meeuwes","sequence":"first","affiliation":[{"name":"Department of Public Health Academic Medical Centre, University of Amsterdam Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. 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