{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T11:28:22Z","timestamp":1774438102739,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,10,31]],"date-time":"2013-10-31T00:00:00Z","timestamp":1383177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Anaemia in children living in sub\u2010Saharan Africa is common, but its causes are diverse. In 545 children below 5\u00a0years of age from rural southern <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>wanda, we assessed the role of iron deficiency (ID) and of the <jats:italic>TMPRSS6<\/jats:italic> 736(V) (rs855791) allele, known to reduce iron status and haemoglobin (Hb) levels, in anaemia and Hb concentrations. Anaemia (Hb &lt;11\u00a0g\/dl) was present in 34.4% of the children and ID (ferritin &lt;12\u00a0ng\/ml) in 17.6%. The <jats:italic>TMPRSS6<\/jats:italic> 736(V) allele was uncommon (allele frequency, 0.096) and not associated with ID. In multivariate analysis, ID was positively associated with anaemia (adjusted odds ratio, 1.67) to an extent comparable with \u03b1<jats:sup>+<\/jats:sup>\u2010thalassaemia, breastfeeding, inflammation and low household income, but the odds were substantially higher in <jats:italic>Plasmodium falciparum<\/jats:italic> infection (adjusted odds ratio, 10.3). These findings were verified in a multivariate analysis of Hb concentrations. The <jats:italic>TMPRSS6<\/jats:italic> 736(V) allele only tended to be associated with low Hb levels. <jats:italic>TMPRSS6<\/jats:italic> 736(V) is comparatively rare among <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>wandan children and may only slightly contribute to low Hb concentrations. Preventable causes of anaemia, notably ID and <jats:italic>P.\u00a0falciparum<\/jats:italic> infection, largely outweigh its impact and need to be addressed to improve the haematological status of children in the study area.<\/jats:p>","DOI":"10.1111\/tmi.12216","type":"journal-article","created":{"date-parts":[[2013,10,31]],"date-time":"2013-10-31T13:44:58Z","timestamp":1383227098000},"page":"117-122","source":"Crossref","is-referenced-by-count":15,"title":["Anaemia, iron deficiency and a common polymorphism of iron\u2010regulation, <i><scp>TMPRSS<\/scp>6<\/i> rs855791, in <scp>R<\/scp>wandan children"],"prefix":"10.1111","volume":"19","author":[{"given":"Ina","family":"Danquah","sequence":"first","affiliation":[{"name":"Department of Molecular Epidemiology German Institute of Human Nutrition Potsdam\u2010Rehbruecke Nuthetal Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Bosco","family":"Gahutu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Butare University Teaching Hospital National University of Rwanda Butare Rwanda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Zeile","sequence":"additional","affiliation":[{"name":"Institute of Tropical Medicine and International Health Charit\u00e9 \u2013 University Medicine Berlin Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andre","family":"Musemakweri","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Butare University Teaching Hospital National University of Rwanda Butare Rwanda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank P.","family":"Mockenhaupt","sequence":"additional","affiliation":[{"name":"Institute of Tropical Medicine and International Health Charit\u00e9 \u2013 University Medicine Berlin Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,10,31]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.456"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.462"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.1989.tb01408.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/134.11.3127"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-10-134"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trstmh.2011.09.002"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2013-101673"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.06.028"},{"key":"e_1_2_6_10_1","volume-title":"Rwanda Demographic and Health Survey 2005","author":"Institut National de la Statistique du Rwanda, ORC Macro","year":"2006"},{"key":"e_1_2_6_11_1","first-page":"869","article-title":"Serum transferrin receptor levels are increased in asymptomatic and mild Plasmodium falciparum\u2010infection","volume":"84","author":"Mockenhaupt FP","year":"1999","journal-title":"Haematologica"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-06-364034"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0035-9203(02)90077-5"},{"key":"e_1_2_6_14_1","unstructured":"World Health Organization.Iron deficiency anaemia: assessment prevention and control. A guide for programme managers. (WHO\/NHD\/01.3).World Health Organization Geneva 2001"},{"key":"e_1_2_6_15_1","volume-title":"Worldwide prevalence of anaemia 1993\u20132005: WHO global database on anaemia","author":"World Health Organization","year":"2008"}],"container-title":["Tropical Medicine &amp; International Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftmi.12216","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tmi.12216","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T10:49:08Z","timestamp":1695552548000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tmi.12216"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,31]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["10.1111\/tmi.12216"],"URL":"https:\/\/doi.org\/10.1111\/tmi.12216","archive":["Portico"],"relation":{},"ISSN":["1360-2276","1365-3156"],"issn-type":[{"value":"1360-2276","type":"print"},{"value":"1365-3156","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,31]]}}}