{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T14:46:29Z","timestamp":1788878789431,"version":"build-2803163510"},"reference-count":14,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,1,17]],"date-time":"2014-01-17T00:00:00Z","timestamp":1389916800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the effect of azithromycin mass drug administration regimens on spleen rates in children aged 0\u20135\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Clinical assessment of spleen size was carried out during a cluster\u2010randomised trial of azithromycin mass treatment for trachoma elimination in The Gambia. Twenty\u2010four communities received three annual mass treatments with azithromycin, and 24 communities received treatment at baseline only.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At the 30\u2010month follow\u2010up, 3646 children aged 0\u20135\u00a0years had spleen examination and measurement. Palpable splenomegaly was significantly lower in annually treated <jats:italic>vs<\/jats:italic>. baseline\u2010only treatment communities and in treated <jats:italic>vs<\/jats:italic>. untreated children at 24\u00a0months in the annual treatment arm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results suggest an effect of azithromycin on spleen rates at the individual level and are most plausibly due to the antimalarial effects of azithromycin.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.12234","type":"journal-article","created":{"date-parts":[[2014,1,17]],"date-time":"2014-01-17T07:22:46Z","timestamp":1389943366000},"page":"207-211","source":"Crossref","is-referenced-by-count":9,"title":["Effect of azithromycin mass drug administration for trachoma on spleen rates in <scp>G<\/scp>ambian children"],"prefix":"10.1111","volume":"19","author":[{"given":"John D.","family":"Hart","sequence":"first","affiliation":[{"name":"Department of Clinical Research London School of Hygiene and Tropical Medicine London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tansy","family":"Edwards","sequence":"additional","affiliation":[{"name":"MRC Tropical Epidemiology Group London School of Hygiene and Tropical Medicine London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah E.","family":"Burr","sequence":"additional","affiliation":[{"name":"Department of Clinical Research London School of Hygiene and Tropical Medicine London UK"},{"name":"Disease Control and Elimination Theme Medical Research Council Unit Fajara The Gambia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma M.","family":"Harding\u2010Esch","sequence":"additional","affiliation":[{"name":"Department of Clinical Research London School of Hygiene and Tropical Medicine London UK"},{"name":"HIV\/STI Department Public Health England London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kensuke","family":"Takaoka","sequence":"additional","affiliation":[{"name":"Department of Clinical Research London School of Hygiene and Tropical Medicine London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin J.","family":"Holland","sequence":"additional","affiliation":[{"name":"Department of Clinical Research London School of Hygiene and Tropical Medicine London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ansumana","family":"Sillah","sequence":"additional","affiliation":[{"name":"National Eye Health Programme Ministry of Health and Social Welfare Kanifing The Gambia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C. W.","family":"Mabey","sequence":"additional","affiliation":[{"name":"Department of Clinical Research London School of Hygiene and Tropical Medicine London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin L.","family":"Bailey","sequence":"additional","affiliation":[{"name":"Department of Clinical Research London School of Hygiene and Tropical Medicine London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,1,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61654-2"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00527-07"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006688.pub2"},{"key":"e_1_2_7_5_1","first-page":"11","article-title":"Spleen measurement in malaria","volume":"3","author":"Hackett LW","year":"1944","journal-title":"Journal of the National Malaria Society"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002115"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0026305"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.1266"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)92712-3"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-9-73"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/09286586.2010.545500"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1086\/515071"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1086\/653710"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199911000-00003"},{"key":"e_1_2_7_15_1","first-page":"45","article-title":"Report on the malaria conference in equatorial Africa","volume":"38","author":"World Health Organisation","year":"1951","journal-title":"World Health Organization Technical Report Series"}],"container-title":["Tropical Medicine &amp; International Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftmi.12234","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tmi.12234","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T11:27:40Z","timestamp":1696159660000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tmi.12234"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,17]]},"references-count":14,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["10.1111\/tmi.12234"],"URL":"https:\/\/doi.org\/10.1111\/tmi.12234","archive":["Portico"],"relation":{},"ISSN":["1360-2276","1365-3156"],"issn-type":[{"value":"1360-2276","type":"print"},{"value":"1365-3156","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,17]]}}}