{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T13:14:24Z","timestamp":1781702064724,"version":"3.54.5"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,3,20]],"date-time":"2014-03-20T00:00:00Z","timestamp":1395273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate the impact of the Three Gorges Dam on the local ecological environment. We conducted a 3\u2010year cross\u2010sectional survey of natural focus infectious diseases in the area before and after the water level rose to 156\u00a0m to evaluate the dam's health impacts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Direct and indirect immunofluorescence methods were applied to detect rat antigen and antibody of haemorrhagic fever with renal syndrome (HFRS). Fresh rat kidneys were inoculated in Korth's culture medium to detect <jats:italic>Leptospira<\/jats:italic>. A group of captured crabs were ground to observe the metacercariae of <jats:italic>Paragonimus<\/jats:italic>. Serum samples were collected from healthy local individuals. <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content> kits were used to detect human antibody against <jats:styled-content style=\"fixed-case\">HFRS<\/jats:styled-content> and paragonimiasis. Human <jats:italic>Leptospira<\/jats:italic> infections were detected by a microscopic agglutination test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Upstream rodent density increased significantly with <jats:italic>Rattus flavipectus<\/jats:italic> and <jats:italic>Apodemus agrarius<\/jats:italic> as the major pathophoric genera. The infection rate of human <jats:styled-content style=\"fixed-case\">HFRS<\/jats:styled-content> and <jats:italic>Leptospira<\/jats:italic> in the upstream human population samples was significantly higher than in the downstream samples and correlated with the increase in rodent density. <jats:italic>Paragonimus<\/jats:italic> infection rates remained at a low level during the study. <jats:italic>Culex pipiens fatigan<\/jats:italic> and <jats:italic>Armigeres obturbans<\/jats:italic> were the dominant species of mosquito.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The creation of the Three Gorges Dam changed the proliferation of intermediary agents of diseases, but not notably. However, the ecological effects on the environment may require a prolonged period of time to manifest themselves; thus, long\u2010term and effective surveillance of vectors and related diseases needs to be established.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.12272","type":"journal-article","created":{"date-parts":[[2014,3,27]],"date-time":"2014-03-27T10:11:01Z","timestamp":1395915061000},"page":"440-449","source":"Crossref","is-referenced-by-count":9,"title":["Response of primary vectors and related diseases to impoundment by the Three Gorges Dam"],"prefix":"10.1111","volume":"19","author":[{"given":"Xu","family":"Zhang","sequence":"first","affiliation":[{"name":"MOE Key Lab of Environment and Health School of Public Health Tongji Medical College Wuhan PRC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangbin","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Statistics School of Public Health Tongji Medical 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