{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T12:14:34Z","timestamp":1789820074074,"version":"4.0.1"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,2,5]],"date-time":"2014-02-05T00:00:00Z","timestamp":1391558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The Institute of Tropical Medicine, Antwerp through the Belgian cooperation Framework Agreement 3 (FA3)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Artemisinin\u2010based combination therapies (ACTs) are essential for the effective control of <jats:italic>falciparum<\/jats:italic> malaria in endemic countries. However, in most countries, such choice has been carried out without knowing their effectiveness when deployed in real\u2010life conditions, that is, when treatment is not directly observed. We report here the results of a study assessing the effectiveness of the two ACTs currently recommended in Burkina Faso for the treatment of uncomplicated malaria, that is, artemether\u2013lumefantrine (<jats:styled-content style=\"fixed-case\">AL<\/jats:styled-content>) and artesunate\u2013amodiaquine (<jats:styled-content style=\"fixed-case\">ASAQ<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between September 2008 and January 2010, 340 children were randomised to one of the two study arms and followed up for 42\u00a0days. Treatment was administered according to routine practices, that is, the first dose was given by study nurses who explained to the parent\/guardian how to administer the other doses at home during the following 2\u00a0days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The results showed a significantly higher unadjusted adequate clinical and parasitological response in the <jats:styled-content style=\"fixed-case\">ASAQ<\/jats:styled-content> (58.4%) than in the <jats:styled-content style=\"fixed-case\">AL<\/jats:styled-content> arm (46.1%) at day 28 but these trends were similar after correction with <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> data (<jats:styled-content style=\"fixed-case\">ASAQ<\/jats:styled-content> (89.7%) and <jats:styled-content style=\"fixed-case\">AL<\/jats:styled-content> (89.8%)). New infections started to appear after day 14, first in the <jats:styled-content style=\"fixed-case\">AL<\/jats:styled-content> and then in the <jats:styled-content style=\"fixed-case\">ASAQ<\/jats:styled-content> arm but at day 42\u00a0day of follow\u2010up we observed no difference in the occurrence of recrudescent infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Despite a lower cure rate than those reported in efficacy studies in which the treatment administration was directly observed, both <jats:styled-content style=\"fixed-case\">AL<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">ASAQ<\/jats:styled-content> can still be used for the treatment of uncomplicated malaria in Burkina Faso.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.12274","type":"journal-article","created":{"date-parts":[[2014,2,5]],"date-time":"2014-02-05T07:56:49Z","timestamp":1391587009000},"page":"469-475","source":"Crossref","is-referenced-by-count":25,"title":["Effectiveness of artesunate\u2013amodiaquine <i>vs<\/i>. artemether\u2013lumefantrine for the treatment of uncomplicated <i>falciparum<\/i> malaria in Nanoro, Burkina Faso: a non\u2010inferiority randomised trial"],"prefix":"10.1111","volume":"19","author":[{"given":"Halidou","family":"Tinto","sequence":"first","affiliation":[{"name":"Unit\u00e9 de Recherche sur le Paludisme et les Maladies Tropicales N\u00e9glig\u00e9es Centre Muraz Bobo\u2010Dioulasso Burkina Faso"},{"name":"Institut de Recherche en Sciences de la Sant\u00e9 Direction R\u00e9gionale Bobo\u2010Dioulasso Burkina Faso"},{"name":"Clinical Research Unit of Nanoro Nanoro Burkina 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