{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T23:31:03Z","timestamp":1722468663059},"reference-count":50,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,3,24]],"date-time":"2014-03-24T00:00:00Z","timestamp":1395619200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Directorate-General for Development"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the impact of periodic selective treatment with 500\u00a0mg mebendazole on soil\u2010transmitted helminth (<jats:styled-content style=\"fixed-case\">STH<\/jats:styled-content>) infections in Cuban schoolchildren.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We followed up a cohort of 268 <jats:styled-content style=\"fixed-case\">STH<\/jats:styled-content>\u2010positive schoolchildren, aged 5\u201314\u00a0years at baseline, at six\u2010month intervals for two years and a final follow\u2010up after three years. Kato\u2010Katz stool examination was used to detect infections with <jats:italic>Ascaris lumbricoides<\/jats:italic>,<jats:italic> Trichuris trichiura<\/jats:italic> and hookworm. Common risk factors related to <jats:styled-content style=\"fixed-case\">STH<\/jats:styled-content>s were assessed by parental questionnaire.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A significant reduction in the number of <jats:styled-content style=\"fixed-case\">STH<\/jats:styled-content> infections was obtained after three years with the highest reduction for <jats:italic>T.\u00a0trichiura<\/jats:italic> (87.8%) and the lowest for hookworm (57.9%). After six months, cure rates (<jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content>s) were 76.9% for <jats:italic>A.\u00a0lumbricoides<\/jats:italic>, 67.4% for <jats:italic>T.\u00a0trichiura<\/jats:italic> and 44.4% for hookworm. After two treatment rounds, more than 75% of all <jats:styled-content style=\"fixed-case\">STH<\/jats:styled-content>\u2010positive children at baseline were cured, but with important differences between <jats:styled-content style=\"fixed-case\">STH<\/jats:styled-content> species (95.2% for <jats:italic>A.\u00a0lumbricoides<\/jats:italic>, 80.5% for <jats:italic>T.\u00a0trichiura<\/jats:italic> and 76.5% for hookworm). At the end of the study, these cumulative <jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content>s were almost 100% for all three <jats:styled-content style=\"fixed-case\">STH<\/jats:styled-content>s. Risk factors for <jats:styled-content style=\"fixed-case\">STH<\/jats:styled-content>s were sex, sanitary disposal and habit of playing in the soil.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results indicate that periodic selective treatment with 500\u00a0mg mebendazole is effective in reducing the number of <jats:styled-content style=\"fixed-case\">STH<\/jats:styled-content> infections in Cuban schoolchildren. Although important differences were found between helminth species, two rounds of treatment appeared sufficient to obtain substantial reductions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.12290","type":"journal-article","created":{"date-parts":[[2014,3,24]],"date-time":"2014-03-24T23:47:51Z","timestamp":1395704871000},"page":"706-718","source":"Crossref","is-referenced-by-count":7,"title":["Impact of periodic selective mebendazole treatment on soil\u2010transmitted helminth infections in Cuban schoolchildren"],"prefix":"10.1111","volume":"19","author":[{"given":"Suzanne D.","family":"van der Werff","sequence":"first","affiliation":[{"name":"Department of Health Sciences VU University Amsterdam Amsterdam the Netherlands"},{"name":"Department of Biomedical Sciences Prince Leopold Institute of Tropical Medicine Antwerp Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim","family":"Vereecken","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Prince Leopold Institute of Tropical Medicine Antwerp Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim","family":"van der Laan","sequence":"additional","affiliation":[{"name":"Department of Health Sciences VU University Amsterdam Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maiza","family":"Campos Ponce","sequence":"additional","affiliation":[{"name":"Department of Health Sciences VU University Amsterdam Amsterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel","family":"Junco D\u00edaz","sequence":"additional","affiliation":[{"name":"National Institute of Hygiene, Epidemiology and Microbiology Havana Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fidel A.","family":"N\u00fa\u00f1ez","sequence":"additional","affiliation":[{"name":"Pedro Kour\u00ed Institute Havana Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00e1zara","family":"Rojas Rivero","sequence":"additional","affiliation":[{"name":"Pedro Kour\u00ed Institute Havana Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariano","family":"Bonet Gorbea","sequence":"additional","affiliation":[{"name":"National Institute of Hygiene, Epidemiology and Microbiology Havana Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katja","family":"Polman","sequence":"additional","affiliation":[{"name":"Department of Health Sciences VU University Amsterdam Amsterdam the Netherlands"},{"name":"Department of Biomedical Sciences Prince Leopold Institute of Tropical Medicine Antwerp Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,3,24]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"577","article-title":"Control of intestinal parasitic infections in Seychelles: a comprehensive and sustainable approach","volume":"74","author":"Albonico M","year":"1996","journal-title":"Bulletin of the World Health Organization"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1179\/000349802125001942"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b605"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-706X(03)00060-3"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7412.431"},{"key":"e_1_2_6_7_1","first-page":"10","article-title":"El tratamiento antihelm\u00edntico selectivo frente al tratamiento masivo. 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