{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T22:15:23Z","timestamp":1791152123064,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2014,6,26]],"date-time":"2014-06-26T00:00:00Z","timestamp":1403740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2014,9]]},"abstract":"Abstract<\/jats:title>Objective<\/jats:title>To assess the effectiveness of IPT<\/jats:styled-content>p in two areas with different malaria transmission intensities.<\/jats:p><\/jats:sec>Methods<\/jats:title>Prospective observational study recruiting pregnant women in two health facilities in areas with high and low malaria transmission intensities. A structured questionnaire was used for interview. Maternal clinic cards and medical logs were assessed to determine drug intake. Placental parasitaemia was screened using both light microscopy and real\u2010time quantitative PCR<\/jats:styled-content>.<\/jats:p><\/jats:sec>Results<\/jats:title>Of 350 pregnant women were recruited and screened for placental parasitaemia, 175 from each area. Prevalence of placental parasitaemia was 16.6% (CI<\/jats:styled-content> 11.4\u201322.9) in the high transmission area and 2.3% (CI<\/jats:styled-content> 0.6\u20135.7) in the low transmission area. Being primigravida and residing in a high transmission area were significant risk factors for placental malaria (OR<\/jats:styled-content> 2.4; CI<\/jats:styled-content> 1.1\u20135.0; P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.025) and (OR<\/jats:styled-content> 9.4; CI<\/jats:styled-content> 3.2\u201327.7; P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.001), respectively. IPT<\/jats:styled-content>p was associated with a lower risk of placental malaria (OR<\/jats:styled-content> 0.3; CI<\/jats:styled-content> 0.1\u20131.0; P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.044); the effect was more pronounced in the high transmission area (OR<\/jats:styled-content> 0.2; CI<\/jats:styled-content> 0.06\u20130.7; P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.015) than in the low transmission area (OR<\/jats:styled-content> 0.4; CI<\/jats:styled-content> 0.04\u20134.5; P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.478). IPT<\/jats:styled-content>p use was not associated with reduced risk of maternal anaemia or low birthweight, regardless of transmission intensity. The number needed to treat (NNT<\/jats:styled-content>) was four (CI<\/jats:styled-content> 2\u20136) women in the high transmission area and 33 (20\u201350) in the low transmission area to prevent one case of placental malaria.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>IPT<\/jats:styled-content>p may have an effect on lowering the risk of placental malaria in areas of high transmission, but this effect did not translate into a benefit on risks of maternal anaemia or low birthweight. The NNT<\/jats:styled-content> needs to be considered, and weighted against that of other protective measures, eventually targeting areas which are above a certain threshold of malaria transmission to maximise the benefit.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.12349","type":"journal-article","created":{"date-parts":[[2014,6,26]],"date-time":"2014-06-26T09:54:06Z","timestamp":1403776446000},"page":"1048-1056","source":"Crossref","is-referenced-by-count":28,"title":["Effectiveness of intermittent preventive treatment with sulfadoxine\u2013pyrimethamine during pregnancy on placental malaria, maternal anaemia and birthweight in areas with high and low malaria transmission intensity in T<\/scp>anzania"],"prefix":"10.1111","volume":"19","author":[{"given":"Dominic","family":"Mosha","sequence":"first","affiliation":[{"name":"Ifakara Health Institute Rufiji HDSS Rufiji Tanzania"},{"name":"Swiss Tropical and Public Health Institute University of Basel Basel 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Switzerland"},{"name":"Infectious Disease Service & Department of Ambulatory Care and Community Medicine University of Lausanne Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,6,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"523","DOI":"10.4269\/ajtmh.2009.80.523","article-title":"Five\u2010year surveillance of molecular markers of Plasmodium falciparum antimalarial drug resistance in Korogwe District, Tanzania: accumulation of the 581G mutation in the P. falciparum dihydropteroate synthase gene","volume":"80","author":"Alifrangis M","year":"2009","journal-title":"American Journal of Tropical Medicine and 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