{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:52:37Z","timestamp":1760122357121},"reference-count":33,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,7,22]],"date-time":"2014-07-22T00:00:00Z","timestamp":1405987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Faculty of Medicine, National University of Malaysia"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To determine the behavioural impact of chemotherapy in survivors of acute lymphoblastic leukaemia (ALL) treated with chemotherapy only and to identify treatment\u2010related or sociodemography\u2010related factors that might be associated with behavioural outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We examined 57 survivors of childhood ALL, who were off treatment for at least 2\u00a0years and were in remission, aged 4\u201318\u00a0years, and 221 unrelated healthy controls. The Child Behaviour Checklist (CBCL) parent report was used either in English or in Bahasa Malaysia (the national language of Malaysia) to assess the behavioural outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Childhood ALL survivors had significantly higher scores on externalising behaviour on the CBCL parent report than did controls. Higher problem scores were found in ALL survivors with single parents on \u2018total problems\u2019 (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.03) and subscales \u2018withdrawn\u2019 (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.03), \u2018social problems\u2019 (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01) and \u2018delinquent behaviour\u2019 (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.03) than in survivors with married parents. Significant associations were seen between a lower education level of the father and the variables representing internalising (withdrawn, anxious\/depressed) and externalising (aggressive behaviour). We observed trends on higher scores in all scales in ALL survivors with single parents than in controls with single parents or with fathers with low education level, especially primary education only.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Malaysian childhood ALL survivors had a significantly increased risk for externalising behavioural problems, and there was a trend towards increased risk of problems in many other behavioural scales. Understanding the sociocultural dimension of patients\u2019 health is important to be able to design the most appropriate remedy for problem behaviours detected in this multi\u2010ethnic population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.12358","type":"journal-article","created":{"date-parts":[[2014,7,22]],"date-time":"2014-07-22T07:27:39Z","timestamp":1406014059000},"page":"1177-1184","source":"Crossref","is-referenced-by-count":3,"title":["Parental reports of behavioural outcome among paediatric leukaemia survivors in Malaysia: a single institution experience"],"prefix":"10.1111","volume":"19","author":[{"given":"Alias","family":"Hamidah","sequence":"first","affiliation":[{"name":"Department of Pediatrics National University of Malaysia Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohd","family":"Sham Marina","sequence":"additional","affiliation":[{"name":"Department of Pediatrics National University of Malaysia Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azmi M.","family":"Tamil","sequence":"additional","affiliation":[{"name":"Department of Public Health National University of Malaysia Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u2010Khai","family":"Loh","sequence":"additional","affiliation":[{"name":"Department of Pediatrics National University of Malaysia Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Latiff A.","family":"Zarina","sequence":"additional","affiliation":[{"name":"Department of Pediatrics National University of Malaysia Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rahman","family":"Jamal","sequence":"additional","affiliation":[{"name":"Department of Pediatrics National University of Malaysia Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohd Daud","family":"Tuti Iryani","sequence":"additional","affiliation":[{"name":"Department of Psychiatry National University of Malaysia Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vijayalakshmi C.","family":"Ratnam","sequence":"additional","affiliation":[{"name":"Department of Pediatrics National University of Malaysia Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,7,22]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"Integrative Guide for 2001 CBCL Profiles","author":"Achenbach TM","year":"2001"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1037\/0893-3200.15.3.355"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.70.6.476"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24909"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.53.0808"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21820"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0009922809332680"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21798"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19980101)82:1<208::AID-CNCR26>3.0.CO;2-5"},{"key":"e_1_2_7_11_1","unstructured":"HowladerN NooneAM KrapchoMet\u00a0al. 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