{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T13:44:57Z","timestamp":1782481497776,"version":"3.54.5"},"reference-count":45,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,10,20]],"date-time":"2014-10-20T00:00:00Z","timestamp":1413763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002878","name":"Consejer\u00eda Econom\u00eda, Innovaci\u00f3n, Ciencia y Empleo, Junta de Andalucia","doi-asserted-by":"publisher","award":["P07-CVI-03249"],"award-info":[{"award-number":["P07-CVI-03249"]}],"id":[{"id":"10.13039\/501100002878","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Therapy against anisakiasis requires invasive techniques to extract <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content><jats:sub>3<\/jats:sub>, and an effective drug against this nematode is needed. The aim of this study was to determine the efficacy of peppermint essential oil (<jats:styled-content style=\"fixed-case\">EO<\/jats:styled-content>) and its main components against the parasite in comparison to albendazole, a drug currently prescribed to treat anisakiasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted <jats:italic>in vitro<\/jats:italic> experiments and studied an experimental model simulating the human infection in <jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>istar rats. We used polymerase chain reaction restriction fragment length polymorphism to identify <jats:italic><jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>.\u00a0simplex<\/jats:italic> s.s. and <jats:italic><jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>.\u00a0pegreffii<\/jats:italic> and determine any differences in their pathogenicity and susceptibility to the treatments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic> experiments both showed that the larvicidal activity of peppermint <jats:styled-content style=\"fixed-case\">EO<\/jats:styled-content>, menthol, menthone and menthyl acetate is higher than that of albendazole. Large stomach lesions were observed in 46.7% of the albendazole\u2010treated rats, whereas no gastrointestinal lesions were detected in those treated with peppermint <jats:styled-content style=\"fixed-case\">EO<\/jats:styled-content>, menthol, menthyl acetate or menthone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this animal model, treatment with peppermint <jats:styled-content style=\"fixed-case\">EO<\/jats:styled-content> or its main components was more effective than was treatment with albendazole. Lesions were more frequently produced by <jats:italic><jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>.\u00a0simplex<\/jats:italic> s.s. larvae than by <jats:italic><jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>.\u00a0pegreffii<\/jats:italic> larvae.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.12399","type":"journal-article","created":{"date-parts":[[2014,10,20]],"date-time":"2014-10-20T08:36:29Z","timestamp":1413794189000},"page":"1430-1436","source":"Crossref","is-referenced-by-count":22,"title":["Peppermint (<i><scp>M<\/scp>entha piperita<\/i>) and albendazole against anisakiasis in an animal model"],"prefix":"10.1111","volume":"19","author":[{"given":"Ma Carmen","family":"Romero","sequence":"first","affiliation":[{"name":"Department of Parasitology University of Granada Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma Concepci\u00f3n","family":"Navarro","sequence":"additional","affiliation":[{"name":"Department of Pharmacology University of Granada Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaquina","family":"Mart\u00edn\u2010S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Department of Parasitology University of Granada Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adela","family":"Valero","sequence":"additional","affiliation":[{"name":"Department of Parasitology University of Granada Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,10,20]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"Identification of Essential Oil Components by Gas Chromatography\/Quadrupole Mass Spectrometry","author":"Adams RP","year":"2001"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2005.09.004"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/00364827.1961.10410245"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2013.05.008"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2011.07.051"},{"key":"e_1_2_6_7_1","first-page":"463","article-title":"Anisakiasis digestiva: cl\u00ednica y diagn\u00f3stico seg\u00fan localizaci\u00f3n","volume":"94","author":"Cast\u00e1n B","year":"2002","journal-title":"Revista Espa\u00f1ola de Enfermedades Digestivas"},{"key":"e_1_2_6_8_1","first-page":"121","article-title":"Anisakiase et infections par les anisakid\u00e9s","volume":"142","author":"Cocheton JJ","year":"1991","journal-title":"Annals of Internal Medicine"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7519(99)00178-2"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(00)90194-5"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2565(02)70979-X"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1997.tb02603.x"},{"key":"e_1_2_6_13_1","unstructured":"Del ReyA(2003).Estudio parasitol\u00f3gico epidemiol\u00f3gico y cl\u00ednico de la anisakidosis en la comarca de Antequera. 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