{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T18:45:10Z","timestamp":1778265910412,"version":"3.51.4"},"reference-count":16,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2014,10,14]],"date-time":"2014-10-14T00:00:00Z","timestamp":1413244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To examine the utility of laboratory methods other than bacterial culture in diagnosing acute bacterial meningitis (<jats:styled-content style=\"fixed-case\">ABM<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Bayesian latent class analysis was used to estimate diagnostic precision of cerebrospinal fluid (<jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content>) culture, leucocyte counts and protein concentrations for <jats:styled-content style=\"fixed-case\">ABM<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>elanesian children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>With a cut\u2010off of \u226520\u00a0leucocytes\/mm<jats:sup>3<\/jats:sup>, the area under the receiver operating characteristic curve (<jats:styled-content style=\"fixed-case\">AUC ROC<\/jats:styled-content>) was &gt;97.5% for leucocyte counts. A lower (93%) <jats:styled-content style=\"fixed-case\">AUC ROC<\/jats:styled-content> was observed for <jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content> protein concentrations \u22651\u00a0g\/l. <jats:styled-content style=\"fixed-case\">CSF<\/jats:styled-content> culture had poor sensitivity and high specificity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Leucocyte counts provide sufficient diagnostic precision to aid clinical decision\u2010making in <jats:styled-content style=\"fixed-case\">ABM<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.12400","type":"journal-article","created":{"date-parts":[[2014,10,15]],"date-time":"2014-10-15T04:04:44Z","timestamp":1413345884000},"page":"1520-1524","source":"Crossref","is-referenced-by-count":8,"title":["Accuracy of cerebrospinal leucocyte count, protein and culture for the diagnosis of acute bacterial meningitis: a comparative study using <scp>B<\/scp>ayesian latent class analysis"],"prefix":"10.1111","volume":"19","author":[{"given":"Laurens","family":"Manning","sequence":"first","affiliation":[{"name":"School of Medicine and Pharmacology Fremantle Hospital University of Western Australia Fremantle WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moses","family":"Laman","sequence":"additional","affiliation":[{"name":"School of Medicine and Pharmacology Fremantle Hospital University of Western Australia Fremantle WA Australia"},{"name":"Papua New Guinea Institute of Medical Research Madang Papua New Guinea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trevor","family":"Mare","sequence":"additional","affiliation":[{"name":"Papua New Guinea Institute of Medical Research Madang Papua New Guinea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilomo","family":"Hwaiwhanje","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Modilon General Hospital Madang Papua New Guinea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Siba","sequence":"additional","affiliation":[{"name":"Papua New Guinea Institute of Medical Research Madang Papua New Guinea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy M. 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