{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T16:00:51Z","timestamp":1781712051553,"version":"3.54.5"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,10,16]],"date-time":"2014-10-16T00:00:00Z","timestamp":1413417600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>A and B blood group antigens are fucosylated carbohydrate present on human erythrocytes and body secretions. Their presence in body secretions depends on the expression of a dominant allele of secretor gene <jats:italic><jats:styled-content style=\"fixed-case\">FUT<\/jats:styled-content>2<\/jats:italic> and is correlated with susceptibility to various infectious and non\u2010infectious diseases. We investigated the correlation of blood group and <jats:styled-content style=\"fixed-case\">ABH<\/jats:styled-content> antigen secretion with <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>elicobacter pylori<\/jats:italic> infection and gastroduodenal symptoms and analysed the distribution of <jats:italic>bab<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content><\/jats:italic> gene among <jats:styled-content style=\"fixed-case\">ABH<\/jats:styled-content> secretors and non\u2010secretors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two hundred and ninety patients who underwent gastroduodenal endoscopy during 2011 to 2012 participated. Gastric biopsy, saliva and blood samples were obtained from every patient. Gastric biopsies were subjected to rapid urease test and <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> for the detection of <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>.\u00a0pylori<\/jats:italic> and <jats:italic>bab<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content><\/jats:italic> gene. Blood grouping and <jats:styled-content style=\"fixed-case\">ABH<\/jats:styled-content> antigens secretions were determined by Lewis blood group phenotyping and haemagglutination inhibition test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>50.34% of patients were <jats:styled-content style=\"fixed-case\">ABH<\/jats:styled-content> antigen secretors and 45.51% non\u2010secretors. Distribution analysis of blood group revealed that 40 blood group B, 67 blood group A 20 blood group O and 19 blood group <jats:styled-content style=\"fixed-case\">AB<\/jats:styled-content> patients secreted <jats:styled-content style=\"fixed-case\">ABH<\/jats:styled-content> antigens in saliva. Fifty\u2010six blood group O, 19 blood group B, 32 blood group A and 17 blood group <jats:styled-content style=\"fixed-case\">AB<\/jats:styled-content> patients were non\u2010secretors. Gastroduodenal complaints were common among non\u2010secretors. Sixty\u2010two percent of patients with a combination of duodenal ulcer and gastro\u2010oesophageal reflux and 54% of patients with gastritis were non\u2010secretors. Of 290 samples, 31.02% were positive for <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>.\u00a0pylori<\/jats:italic>. Thirty percent of these tested positive for <jats:italic>bab<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content><\/jats:italic> gene; the majority belonged to non\u2010secretor blood group O.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results suggest that the infection of <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>.\u00a0pylori<\/jats:italic> is correlated with <jats:styled-content style=\"fixed-case\">ABO<\/jats:styled-content> blood groups and blood group antigens secretion in body fluids.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.12401","type":"journal-article","created":{"date-parts":[[2014,10,17]],"date-time":"2014-10-17T03:23:23Z","timestamp":1413516203000},"page":"115-119","source":"Crossref","is-referenced-by-count":7,"title":["Correlation of <scp>ABH<\/scp> blood group antigens secretion with <i><scp>H<\/scp>elicobacter pylori<\/i> infection in Pakistani patients"],"prefix":"10.1111","volume":"20","author":[{"given":"Shazia Akbar","family":"Ansari","sequence":"first","affiliation":[{"name":"Immunology and Infectious Diseases Research Laboratory Department of Microbiology University of Karachi Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adnan","family":"Khan","sequence":"additional","affiliation":[{"name":"Immunology and Infectious Diseases Research Laboratory Department of Microbiology University of Karachi Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taseer Ahmed","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Physiology University of Karachi Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasir","family":"Raza","sequence":"additional","affiliation":[{"name":"Immunology and Infectious Diseases Research Laboratory Department of Microbiology University of Karachi Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia Ali","family":"Syed","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology Dow Dental College Dow University of Health Sciences Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed Shakeel","family":"Akhtar","sequence":"additional","affiliation":[{"name":"Department of Medicine Civil Hospital Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahana Urooj","family":"Kazmi","sequence":"additional","affiliation":[{"name":"Immunology and Infectious Diseases Research Laboratory Department of Microbiology University of Karachi Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,10,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.3329\/fmcj.v6i1.7409"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1098801"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781118493595"},{"key":"e_1_2_6_5_1","first-page":"225","article-title":"Non\u2010secretor status; 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