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Studies were evaluated in accordance with <jats:styled-content style=\"fixed-case\">QUADAS<\/jats:styled-content> 2 and <jats:styled-content style=\"fixed-case\">STARD<\/jats:styled-content> parameters and recommended in accordance with <jats:styled-content style=\"fixed-case\">GRADE<\/jats:styled-content> parameters. Meta\u2010analysis was carried out with Meta\u2010DiSc software, using the random\u2010effect model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two hundred and eighty\u2010four studies were identified, of which 25 met the inclusion criteria, comprising the final synthesis. All but one was conducted in Brazil, and only two were judged to be of good quality. 15 studies involving immuno\u2010enzymatic tests with crude antigens (<jats:styled-content style=\"fixed-case\">cELISA<\/jats:styled-content>), 11 studies on indirect immunofluorescence tests (IFAT) and three on the immunochromatographic dual\u2010path platform (DPP) test were meta\u2010analysed. The combined results for sensitivity and specificity were <jats:styled-content style=\"fixed-case\">cELISA<\/jats:styled-content>: 0.89 (CI 95% 0.87\u20130.91) and 0.87 (CI 95% 0.86\u20130.88); IFAT: 0.88 (CI 95% 0.85\u20130.91) and 0.63 (CI 95% 0.61\u20130.65); and DPP: 0.83 (CI 95% 0.78\u20130.88) and 0.73 (CI 95% 0.70\u20130.75).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Enzyme\u2010linked immunosorbent assay with crude antigens and DPP tests have moderate accuracy for the diagnosis of canine visceral leishmaniasis, and the quality of the design, implementation and analysis of validation studies on diagnostic tests for this disease urgently require improvement. The recommendation for use of the evaluated tests is based on evidence that is scarce and restricted to <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>razil.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.12429","type":"journal-article","created":{"date-parts":[[2014,11,18]],"date-time":"2014-11-18T07:46:11Z","timestamp":1416296771000},"page":"334-352","source":"Crossref","is-referenced-by-count":51,"title":["Serological diagnosis of canine visceral leishmaniasis in <scp>B<\/scp>razil: systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"20","author":[{"given":"Henry Maia","family":"Peixoto","sequence":"first","affiliation":[{"name":"Center for Tropical Medicine University of Bras\u00edlia Bras\u00edlia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Regina Fernandes","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Center for Tropical Medicine University of Bras\u00edlia Bras\u00edlia Brazil"},{"name":"National Institute for Science and Technology for Health Technology Assessment Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo Adolfo Sierra","family":"Romero","sequence":"additional","affiliation":[{"name":"Center for Tropical Medicine University of Bras\u00edlia Bras\u00edlia Brazil"},{"name":"National Institute for Science and Technology for Health Technology Assessment Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,12,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2011.03.001"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0037-86822009000200012"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035671"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2012.07.006"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2008.10.308"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001511"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0069988"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02762007000100001"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2013.03.010"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1766"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-138-1-200301070-00012-w1"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1590\/0037-868216432013"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1678-91992010000300007"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2008.08.010"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002355"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2007.07.007"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0036-46652006000300007"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2006.03.008"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2012.08.007"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-2-9"},{"key":"e_1_2_7_22_1","doi-asserted-by":"crossref","first-page":"40","DOI":"10.4269\/ajtmh.1995.53.40","article-title":"Diagnosis of canine visceral leishmaniasis with a dot\u2010enzyme\u2010linked immunosorbent assay","volume":"53","author":"Dietze R","year":"1995","journal-title":"The American Journal of Tropical Medicine and Hygiene"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001310"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2007.02.015"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0036242"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2009.06.030"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0036-46652010000400005"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0037-86821996000200009"},{"key":"e_1_2_7_29_1","first-page":"104","article-title":"Visceral leishmaniasis in Argentina. 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