{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:12:15Z","timestamp":1791558735231,"version":"4.3.4"},"reference-count":36,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,4,6]],"date-time":"2015-04-06T00:00:00Z","timestamp":1428278400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"MRC (UK)"},{"name":"Global Alliance for Vaccines and Immunisation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate pneumococcal colonisation before and after the introduction of pneumococcal conjugate vaccine (<jats:styled-content style=\"fixed-case\">PCV<\/jats:styled-content>) in eastern Gambia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Population\u2010based cross\u2010sectional survey of pneumococcal carriage between May and August 2009 before the introduction of <jats:styled-content style=\"fixed-case\">PCV<\/jats:styled-content> into the Expanded Program on Immunization. Nasopharyngeal swabs were collected from all household members, but in selected households, only children aged 6\u201310\u00a0years were swabbed. This age group participated in an earlier trial of a nine\u2010valent <jats:styled-content style=\"fixed-case\">PCV<\/jats:styled-content> between 2000 and 2004.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of nasopharyngeal pneumococcal carriage in 2933 individuals was 72.0% in underfives (<jats:italic>N<\/jats:italic>\u00a0=\u00a0515), 41.6% in children aged 5\u201317 (<jats:italic>N<\/jats:italic>\u00a0=\u00a01508) and 13.0% in adults \u226518 (<jats:italic>N<\/jats:italic>\u00a0=\u00a0910)\u00a0years. The age\u2010specific prevalence of serotypes included in <jats:styled-content style=\"fixed-case\">PCV<\/jats:styled-content>7, <jats:styled-content style=\"fixed-case\">PCV<\/jats:styled-content>10 and <jats:styled-content style=\"fixed-case\">PCV<\/jats:styled-content>13 was 24.7%, 26.6% and 46.8% among children &lt;5\u00a0years of age; 8.5%, 9.2% and 17.7% among children 5\u201317\u00a0years; and 2.5%, 3.3% and 5.5% among adults \u226518\u00a0years. The most common serotypes were 6A (13.1%), 23F (7.6%), 3 (7.3%), 19F (7.1%) and 34 (4.6%). There was no difference in the overall carriage of pneumococci between vaccinated and unvaccinated children 8\u00a0years after the primary vaccination with three doses of <jats:styled-content style=\"fixed-case\">PCV<\/jats:styled-content> (48.3% <jats:italic>vs<\/jats:italic>. 41.1%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Before the introduction of <jats:styled-content style=\"fixed-case\">PCV<\/jats:styled-content>, serotypes included in <jats:styled-content style=\"fixed-case\">PCV<\/jats:styled-content>13 accounted for about half the pneumococcal serotypes in nasopharyngeal carriage. Thus, the potential impact of <jats:styled-content style=\"fixed-case\">PCV<\/jats:styled-content>13 on pneumococcal disease in the Gambia is substantial.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.12505","type":"journal-article","created":{"date-parts":[[2015,3,17]],"date-time":"2015-03-17T01:32:55Z","timestamp":1426555975000},"page":"871-879","source":"Crossref","is-referenced-by-count":24,"title":["Pneumococcal carriage in rural Gambia prior to the introduction of pneumococcal conjugate vaccine: a population\u2010based survey"],"prefix":"10.1111","volume":"20","author":[{"given":"Effua","family":"Usuf","sequence":"first","affiliation":[{"name":"Medical Research Council Unit Fajara The Gambia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"Badji","sequence":"additional","affiliation":[{"name":"Medical Research Council Unit Fajara The Gambia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdoulie","family":"Bojang","sequence":"additional","affiliation":[{"name":"Medical Research Council Unit Fajara The Gambia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheikh","family":"Jarju","sequence":"additional","affiliation":[{"name":"Medical Research Council Unit Fajara The Gambia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Usman Nurudeen","family":"Ikumapayi","sequence":"additional","affiliation":[{"name":"Medical Research Council Unit Fajara The Gambia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Antonio","sequence":"additional","affiliation":[{"name":"Medical Research Council Unit Fajara The Gambia"},{"name":"Microbiology and Infection Unit University of Warwick Coventry UK"},{"name":"Faculty of Infectious and Tropical Diseases London School of Hygiene and Tropical Medicine London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grant","family":"Mackenzie","sequence":"additional","affiliation":[{"name":"Medical Research Council Unit Fajara The Gambia"},{"name":"Faculty of Infectious and Tropical Diseases London School of Hygiene and Tropical Medicine London UK"},{"name":"Murdoch Children's Research Institute Melbourne Vic. 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