{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:08:36Z","timestamp":1791202116759,"version":"4.2.0"},"reference-count":22,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,6,28]],"date-time":"2015-06-28T00:00:00Z","timestamp":1435449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"BC Centre for Disease Control Foundation for Population and Public Health"},{"name":"University of British Columbia Development Fund"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To compare two cervical cancer screening methods: community\u2010based self\u2010collection of high\u2010risk human papillomavirus (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>) testing and visual inspection with acetic acid (<jats:styled-content style=\"fixed-case\">VIA<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Pilot randomised controlled trial of 500 women aged 30\u201365 in the community of <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>isenyi, <jats:styled-content style=\"fixed-case\">U<\/jats:styled-content>ganda. Women randomised to self\u2010collection\u2010based <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> testing provided a cervico\u2010vaginal swab for <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>, and results were provided by phone after laboratory testing. Women who tested <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> positive were referred for <jats:styled-content style=\"fixed-case\">VIA<\/jats:styled-content> at the local health unit. Women randomised to <jats:styled-content style=\"fixed-case\">VIA<\/jats:styled-content> underwent screening at the local health unit, where women who tested positive with <jats:styled-content style=\"fixed-case\">VIA<\/jats:styled-content> were provided cryotherapy at time of screening, as per local standard of care. Women were referred for colposcopy when indicated. Outcome measures were uptake of screening, <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> prevalence, <jats:styled-content style=\"fixed-case\">VIA<\/jats:styled-content> result and treatment rates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> arm, 248 of 250 (p\u00a0&lt;\u00a00.01) women provided samples, while in the <jats:styled-content style=\"fixed-case\">VIA<\/jats:styled-content> arm, 121 of 250 (48.4%) women attended screening. Among the 73 of 248 <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>\u2010positive women, 45.2% (<jats:italic>N<\/jats:italic>\u00a0=\u00a033) attended <jats:styled-content style=\"fixed-case\">VIA<\/jats:styled-content> screening for follow\u2010up, 21.2% (<jats:italic>N<\/jats:italic>\u00a0=\u00a07) of whom screened positive; five received treatment and two were missing clinical follow\u2010up records. Of the 121 women in the <jats:styled-content style=\"fixed-case\">VIA<\/jats:styled-content> arm who attended screening, 13.2% (<jats:italic>N<\/jats:italic>\u00a0=\u00a016) screened positive; seven received cryotherapy, three refused treatment, five were referred to colposcopy; and one woman had suspected cervical cancer and received treatment after confirmatory testing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This pilot study demonstrated trial feasibility and willingness of the women to participate and be randomised successfully into the two arms. Self\u2010collection\u2010based cervical cancer screening had a higher uptake than <jats:styled-content style=\"fixed-case\">VIA<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.12549","type":"journal-article","created":{"date-parts":[[2015,5,29]],"date-time":"2015-05-29T19:27:46Z","timestamp":1432927666000},"page":"1355-1367","source":"Crossref","is-referenced-by-count":76,"title":["Uptake of community\u2010based, self\u2010collected <scp>HPV<\/scp> testing <i>vs<\/i>. visual inspection with acetic acid for cervical cancer screening in <scp>K<\/scp>ampala, <scp>U<\/scp>ganda: preliminary results of a randomised controlled trial"],"prefix":"10.1111","volume":"20","author":[{"given":"Erin","family":"Moses","sequence":"first","affiliation":[{"name":"Women's Health Research Institute Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather N.","family":"Pedersen","sequence":"additional","affiliation":[{"name":"University of British Columbia Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheona M.","family":"Mitchell","sequence":"additional","affiliation":[{"name":"University of British Columbia Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Musa","family":"Sekikubo","sequence":"additional","affiliation":[{"name":"Makerere University Kampala Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Mwesigwa","sequence":"additional","affiliation":[{"name":"Kisenyi Health Unit Kampala Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Singer","sequence":"additional","affiliation":[{"name":"University of British Columbia Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Biryabarema","sequence":"additional","affiliation":[{"name":"Makerere University Kampala Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josaphat K.","family":"Byamugisha","sequence":"additional","affiliation":[{"name":"Makerere University Kampala Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah M.","family":"Money","sequence":"additional","affiliation":[{"name":"Women's Health Research Institute Vancouver BC Canada"},{"name":"University of British Columbia Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gina S.","family":"Ogilvie","sequence":"additional","affiliation":[{"name":"Women's Health Research Institute Vancouver BC Canada"},{"name":"University of British Columbia Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,6,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199909)189:1<12::AID-PATH431>3.0.CO;2-F"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61152-X"},{"key":"e_1_2_6_4_1","unstructured":"FerlayJ SoerjomataramI&ErvikM et\u00a0al.GLOBOCAN 2012 Cancer Incidence and Mortality Worldwide.IARC CancerBase.2012;11. (Available from:http:\/\/globocan.iarc.fr) [13 December 2013]."},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-8080(08)32415-X"},{"key":"e_1_2_6_6_1","unstructured":"World Health Organization.Comprehensive Cervical Cancer Control A Guide to Essential Practice \u2010 2nd ed.2014. (Available from:http:\/\/apps.who.int\/iris\/bitstream\/10665\/144785\/1\/9789241548953_eng.pdf?ua=1) [19 December 2014]."},{"key":"e_1_2_6_7_1","unstructured":"World Health Organization.WHO Guidelines for Screening and Treatment of Precancerous Lesions for Cervical Cancer Prevention.2013:40. (Available from:http:\/\/apps.who.int\/iris\/bitstream\/10665\/94830\/1\/9789241548694_eng.pdf?ua=1) [14 November 2014]."},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2006.12.031"},{"key":"e_1_2_6_9_1","unstructured":"World Health Organization.Prevention of Cervical Cancer Through Screening Using Visual Inspection with Acetic Acid (VIA) and Treatment with Cryotherapy: A Demonstration Project in Six African Countries (Malawi Madagascar Nigeria Uganda the United Republic of Tanzania and Zambia).2012. (Available from:http:\/\/apps.who.int\/iris\/bitstream\/10665\/75250\/1\/9789241503860_eng.pdf?ua=1) [01 December 2014]."},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2011.11.004"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2013.03.019"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.27790"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2012.06.031"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61522-5"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.070013"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2011.01.028"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2014-004783"},{"key":"e_1_2_6_18_1","first-page":"e1","article-title":"Factors associated with high\u2010risk HPV positivity in a low\u2010resource setting in sub\u2010Saharan Africa","volume":"1","author":"Mitchell S","year":"2014","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_2_6_19_1","unstructured":"MoneyD MosesE PedersenH SekikuboM MitchellS MwesigwaDet\u00a0al. editors.Cervical cancer screening in women living with HIV using self\u2010collection based human papillomavirus testing in Uganda. 5th International Workshop on HIV & Women;2015; Seattle."},{"key":"e_1_2_6_20_1","unstructured":"Ecoli sro.PCR Diagnostics.Edu.2015. (Available from:http:\/\/www.pcrdiagnostics.eu\/en\/Products\/HPV-Infections.alej) [19 February 2015]."},{"key":"e_1_2_6_21_1","unstructured":"Hain Life Science.GenoQuick Technology. (Available from:http:\/\/www.hain-lifescience.de\/en\/technologies\/genoquick.html) [19 February 2015]."},{"key":"e_1_2_6_22_1","unstructured":"BioScienceS.CinnaGen SmarTaq DNA Polymerase.2013. (Available from:http:\/\/sinaclon.com\/product-31-Real-Time-PCR-Master-Mixes-HotTaq-EvaGreen%C2%AE-qPCR-Mix) [19 February 2015]."},{"key":"e_1_2_6_23_1","doi-asserted-by":"crossref","DOI":"10.1002\/9781118548387","volume-title":"Wiley Series in Probability and Statistics: Applied Logistic Regression","author":"Hosmer DW","year":"2013"}],"container-title":["Tropical Medicine &amp; International Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftmi.12549","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tmi.12549","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T22:40:39Z","timestamp":1696200039000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tmi.12549"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,28]]},"references-count":22,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["10.1111\/tmi.12549"],"URL":"https:\/\/doi.org\/10.1111\/tmi.12549","archive":["Portico"],"relation":{},"ISSN":["1360-2276","1365-3156"],"issn-type":[{"value":"1360-2276","type":"print"},{"value":"1365-3156","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,28]]}}}