{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T06:46:04Z","timestamp":1696229164224},"reference-count":46,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,6,25]],"date-time":"2015-06-25T00:00:00Z","timestamp":1435190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The human mannose\u2010binding lectin (<jats:styled-content style=\"fixed-case\">MBL<\/jats:styled-content>) and ficolins (<jats:styled-content style=\"fixed-case\">FCN<\/jats:styled-content>) are involved in pathogen recognition in the first line of defence. They support activation of the complement lectin cascade in the presence of <jats:styled-content style=\"fixed-case\">MBL<\/jats:styled-content>\u2010associated serine protease 2 (<jats:styled-content style=\"fixed-case\">MASP<\/jats:styled-content>\u20102), a protein that cleaves the C4 and C2 complement components. Recent studies found that distinct <jats:italic><jats:styled-content style=\"fixed-case\">MBL<\/jats:styled-content>2<\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">FCN<\/jats:styled-content>2<\/jats:italic> promoter variants and their corresponding serum levels are associated with relative protection from urogenital schistosomiasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We investigated the contribution of <jats:styled-content style=\"fixed-case\">MASP<\/jats:styled-content>\u20102 levels and <jats:italic><jats:styled-content style=\"fixed-case\">MASP<\/jats:styled-content>2<\/jats:italic> polymorphisms in a Nigerian study group, of 163 individuals infected with <jats:italic>Schistosoma haematobium<\/jats:italic> and 183 healthy subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">MASP<\/jats:styled-content>\u20102 serum levels varied between younger children (\u226412\u00a0years) and older children (&gt;12\u00a0years) and adults (<jats:italic>P\u00a0=\u00a0<\/jats:italic>0.0001). Younger children with a patent infection had significantly lower <jats:styled-content style=\"fixed-case\">MASP<\/jats:styled-content>\u20102 serum levels than uninfected children (<jats:italic>P\u00a0=\u00a0<\/jats:italic>0.0074). Older children and adults (&gt;12\u00a0years) with a current infection had higher serum <jats:styled-content style=\"fixed-case\">MASP<\/jats:styled-content>\u20102 levels than controls (<jats:italic>P\u00a0=\u00a0<\/jats:italic>0.032). <jats:styled-content style=\"fixed-case\">MBL<\/jats:styled-content> serum levels correlated positively with <jats:styled-content style=\"fixed-case\">MASP<\/jats:styled-content>\u20102 serum levels (<jats:italic>P\u00a0=\u00a0<\/jats:italic>0.01). <jats:italic><jats:styled-content style=\"fixed-case\">MASP<\/jats:styled-content>2<\/jats:italic> secretor haplotypes were associated with <jats:styled-content style=\"fixed-case\">MASP<\/jats:styled-content>\u20102 serum levels in healthy subjects. The heterozygous <jats:italic><jats:styled-content style=\"fixed-case\">MASP<\/jats:styled-content>2<\/jats:italic> p.P126L variant was associated with reduced serum <jats:styled-content style=\"fixed-case\">MASP<\/jats:styled-content>\u20102 levels (<jats:italic>P\u00a0=\u00a0<\/jats:italic>0.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The findings indicate that higher <jats:styled-content style=\"fixed-case\">MASP<\/jats:styled-content>\u20102 serum levels are associated with relative protection from urogenital schistosomiasis in Nigerian children.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.12551","type":"journal-article","created":{"date-parts":[[2015,6,5]],"date-time":"2015-06-05T12:42:41Z","timestamp":1433508161000},"page":"1311-1319","source":"Crossref","is-referenced-by-count":2,"title":["Low <scp>MBL<\/scp>\u2010associated serine protease 2 (<scp>MASP<\/scp>\u20102) levels correlate with urogenital schistosomiasis in Nigerian children"],"prefix":"10.1111","volume":"20","author":[{"given":"Olusola","family":"Ojurongbe","sequence":"first","affiliation":[{"name":"Institute of Tropical Medicine University of T\u00fcbingen T\u00fcbingen Germany"},{"name":"Ladoke Akintola University of Technology Ogbomoso Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin S.","family":"Antony","sequence":"additional","affiliation":[{"name":"Institute of Tropical Medicine University of T\u00fcbingen T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hoang","family":"Van Tong","sequence":"additional","affiliation":[{"name":"Institute of Tropical Medicine University of T\u00fcbingen T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian G.","family":"Meyer","sequence":"additional","affiliation":[{"name":"Institute of Tropical Medicine University of T\u00fcbingen T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akeem A.","family":"Akindele","sequence":"additional","affiliation":[{"name":"Ladoke Akintola University of Technology Ogbomoso Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olawumi R.","family":"Sina\u2010Agbaje","sequence":"additional","affiliation":[{"name":"Ogun State Hospital Ijaye Abeokuta Nigeria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter G.","family":"Kremsner","sequence":"additional","affiliation":[{"name":"Institute of Tropical Medicine University of T\u00fcbingen T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thirumalaisamy P.","family":"Velavan","sequence":"additional","affiliation":[{"name":"Institute of Tropical Medicine University of T\u00fcbingen T\u00fcbingen Germany"},{"name":"Fondation Congolaise pour la Recherche Medicale Brazzaville Republic of Congo"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,6,25]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"WHO.Schistosomiasis. 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