{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T09:51:57Z","timestamp":1790070717741,"version":"4.0.1"},"reference-count":23,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,7,24]],"date-time":"2015-07-24T00:00:00Z","timestamp":1437696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe our experiences in the management of a case of Lassa fever (<jats:styled-content style=\"fixed-case\">LF<\/jats:styled-content>) and follow\u2010up of nosocomial primary contacts during the 2014 Ebola outbreak in West Africa.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Clinical management of the index case and infection control\/surveillance activities for primary contacts are described. Laboratory confirmation was by Lassa virus\u2010specific reverse\u2010transcriptase <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A 28\u2010year\u2010old man with a 10\u2010day history of febrile illness was referred to a major tertiary hospital in south\u2010east Nigeria from a city that previously experienced a <jats:styled-content style=\"fixed-case\">LF<\/jats:styled-content> outbreak and was recently affected by Ebola. On observation of haemorrhagic features, clinicians were at a crossroads. Diagnosis of <jats:styled-content style=\"fixed-case\">LF<\/jats:styled-content> was confirmed at a National Reference Centre. The patient died despite initiation of ribavirin therapy. Response activities identified 121 primary contacts comprising 78 (64.5%) hospital staff\/interns, 19 (15.7%) medical students, 18 (14.9%) inpatients and 6 (5.0%) relatives. Their mean age was 32.8\u00a0\u00b1\u00a06.6\u00a0years, and 65.3% were women. Twenty (16.5%) had <jats:italic>high\u2010risk<\/jats:italic> exposure and were offered ribavirin as post\u2010exposure prophylaxis. No secondary case of <jats:styled-content style=\"fixed-case\">LF<\/jats:styled-content> occurred. Fatigue (43.8%) and dizziness (31.3%) were the commonest side effects of ribavirin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Response activities contained nosocomial spread of <jats:styled-content style=\"fixed-case\">LF<\/jats:styled-content>, but challenges were experienced including lack of a purpose\u2010built isolation facility, absence of local Lassa virus laboratory capacity, failure to use appropriate protective equipment and stigmatisation of contacts. A key lesson is that the weak health systems of Africa should be comprehensively strengthened; otherwise, we might win the Ebola battle but lose the one against less virulent infections for which effective treatment exists.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.12565","type":"journal-article","created":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T13:03:17Z","timestamp":1436878997000},"page":"1424-1430","source":"Crossref","is-referenced-by-count":18,"title":["Lessons learnt from the management of a case of Lassa fever and follow\u2010up of nosocomial primary contacts in Nigeria during Ebola virus disease outbreak in West Africa"],"prefix":"10.1111","volume":"20","author":[{"given":"Michael O.","family":"Iroezindu","sequence":"first","affiliation":[{"name":"Department of Medicine University of Nigeria Teaching Hospital, Ituku\/Ozalla Enugu Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uche S.","family":"Unigwe","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Nigeria Teaching Hospital, Ituku\/Ozalla Enugu Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celestine C.","family":"Okwara","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Nigeria Teaching Hospital, Ituku\/Ozalla Enugu Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gladys A.","family":"Ozoh","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Nigeria Teaching Hospital, Ituku\/Ozalla Enugu Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne C.","family":"Ndu","sequence":"additional","affiliation":[{"name":"Department of Community Medicine University of Nigeria Teaching Hospital, Ituku\/Ozalla Enugu Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin E.","family":"Ohanu","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology University of Nigeria Teaching Hospital, Ituku\/Ozalla Enugu Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ugochukwu O.","family":"Nwoko","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Nigeria Teaching Hospital, Ituku\/Ozalla Enugu Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwadiegwu W.","family":"Okoroafor","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Nigeria Teaching Hospital, Ituku\/Ozalla Enugu Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esinulo","family":"Ejimudo","sequence":"additional","affiliation":[{"name":"Nigeria Centre for Disease Control and Prevention Abuja Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaete A.","family":"Tobin","sequence":"additional","affiliation":[{"name":"Institute of Lassa Fever Research and Control Irrua Specialist Hospital Irrua Edo State Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danny A.","family":"Asogun","sequence":"additional","affiliation":[{"name":"Institute of Lassa Fever Research and Control Irrua Specialist Hospital Irrua Edo State Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1970.19.670"},{"key":"e_1_2_6_3_1","first-page":"1","article-title":"Lassa fever in West Africa sub region: an overview","volume":"44","author":"Ogbu O","year":"2007","journal-title":"J Vector Borne Dis"},{"key":"e_1_2_6_4_1","unstructured":"VHFC.Viral haemorrhagic fevers consortium: Lassa fever 2013. 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