{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T11:02:52Z","timestamp":1784890972888,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,9,2]],"date-time":"2015-09-02T00:00:00Z","timestamp":1441152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To determine antibiotic susceptibility of colonising pneumococcal serotypes in <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010exposed infants before the introduction of the 13\u2010valent pneumococcal conjugate vaccine (<jats:styled-content style=\"fixed-case\">PCV<\/jats:styled-content>13), because <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010exposed infants are at increased risk of invasive pneumococcal infections.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Antibiotic susceptibility of 104 pneumococcal isolates, cultured from the nasopharynx from Tanzanian <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010exposed infants, was determined using the disc diffusion method and the <jats:italic>E<\/jats:italic>\u2010test according to <jats:styled-content style=\"fixed-case\">EUCAST<\/jats:styled-content> version 4.0 (2014) criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 69.2% of isolates were intermediately susceptible for benzyl penicillin (<jats:styled-content style=\"fixed-case\">MIC<\/jats:styled-content> 0.06\u20132\u00a0mg\/l ); no high\u2010level resistance was found. All isolates but one were susceptible to ampicillin. Regarding non\u2010beta\u2010lactam antibiotics, 19.2% of isolates were resistant to doxycycline, 3.8% to erythromycin and 97.1% to trimethoprim\/sulfamethoxazole. A total of 15.4% of isolates were resistant to three antibiotic classes or more. There were no differences in antibiotic susceptibility between vaccine and non\u2010vaccine serotypes. Reduced susceptibility of colonising pneumococcal isolates for commonly used antibiotics is common in <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010exposed Tanzanian infants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>High\u2010dose penicillin and ampicillin remain appropriate first choices for non\u2010meningeal pneumococcal infections in this group.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.12582","type":"journal-article","created":{"date-parts":[[2015,7,30]],"date-time":"2015-07-30T10:41:57Z","timestamp":1438252917000},"page":"1559-1563","source":"Crossref","is-referenced-by-count":10,"title":["Antibiotic resistance of <i>Streptococcus pneumoniae<\/i> colonising the nasopharynx of <scp>HIV<\/scp>\u2010exposed Tanzanian infants"],"prefix":"10.1111","volume":"20","author":[{"given":"P.","family":"Bles","sequence":"first","affiliation":[{"name":"Laboratory of Pediatric Infectious Diseases Radboud University Medical Center Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Q.","family":"de Mast","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Radboud University Medical Center Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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