{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T06:21:44Z","timestamp":1777270904778,"version":"3.51.4"},"reference-count":50,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,10,5]],"date-time":"2015-10-05T00:00:00Z","timestamp":1444003200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Group B streptococcal (GBS) colonization of pregnant women can lead to subsequent infection of the new\u2010born and potentially fatal invasive disease. Data on GBS colonization prevalence and serotype distribution from Africa are scarce, although GBS\u2010related infections are estimated to contribute substantially to infant mortality. In recent years, GBS vaccine candidates provided promising results in phase I and II clinical trials. We aimed to assess the prevalence and serotype distribution of GBS in Ghana since this knowledge is a prerequisite for future evaluation of vaccine trials.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This double\u2010centre study was conducted in one rural and one urban hospital in central Ghana, West Africa. Women in late pregnancy (\u226535 weeks of gestation) attending the antenatal care clinic (<jats:styled-content style=\"fixed-case\">ANC<\/jats:styled-content>) provided recto\u2010vaginal swabs for <jats:styled-content style=\"fixed-case\">GBS<\/jats:styled-content> testing. <jats:styled-content style=\"fixed-case\">GBS<\/jats:styled-content> isolates were analysed for serotype and antibiotic susceptibility. <jats:styled-content style=\"fixed-case\">GBS<\/jats:styled-content>\u2010positive women were treated with intrapartum antibiotic prophylaxis (<jats:styled-content style=\"fixed-case\">IAP<\/jats:styled-content>) according to current guidelines of the Center for Disease Control and Prevention (<jats:styled-content style=\"fixed-case\">CDC<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 519 women were recruited at both study sites, recto\u2010vaginal swabs were taken from 509. The overall prevalence of <jats:styled-content style=\"fixed-case\">GBS<\/jats:styled-content> was 19.1% (18.1% in rural Pramso and 23.1% in urban Kumasi, restrospectively). Capsular polysaccharide serotype (<jats:styled-content style=\"fixed-case\">CPS<\/jats:styled-content>) Ia accounted for the most frequent serotype beyond all isolates (28.1%), followed by serotype V (27.1%) and <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> (21.9%). No resistance to Penicillin was found, resistances to second line antibiotics clindamycin and erythromycin were 3.1% and 1%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Group B <jats:italic>Streptococcus<\/jats:italic> serotype distribution in Ghana is similar to that worldwide, but variations in prevalence of certain serotypes between the urban and rural study site were high. Antibiotic resistance of <jats:styled-content style=\"fixed-case\">GBS<\/jats:styled-content> strains was surprisingly low in this study.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.12589","type":"journal-article","created":{"date-parts":[[2015,8,18]],"date-time":"2015-08-18T18:11:31Z","timestamp":1439921491000},"page":"1516-1524","source":"Crossref","is-referenced-by-count":15,"title":["Group B <i>Streptococci<\/i> serotype distribution in pregnant women in Ghana: assessment of potential coverage through future vaccines"],"prefix":"10.1111","volume":"20","author":[{"given":"C. D.","family":"Vinnemeier","sequence":"first","affiliation":[{"name":"Section\u00a0Tropical Medicine University Medical Center Hamburg\u2010Eppendorf Hamburg Germany"},{"name":"Clinical Research Group Bernhard Nocht Institute for Tropical Medicine Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Brust","sequence":"additional","affiliation":[{"name":"Clinical Research Group Bernhard Nocht Institute for Tropical Medicine Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Owusu\u2010Dabo","sequence":"additional","affiliation":[{"name":"Kumasi Center for Collaborative Research in Tropical Medicine Kumasi Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Sarpong","sequence":"additional","affiliation":[{"name":"Infectious Diseases Epidemiology Bernhard Nocht Institute for Tropical Medicine Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. Y.","family":"Sarfo","sequence":"additional","affiliation":[{"name":"St. Michael's Hospital Pramso Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Bio","sequence":"additional","affiliation":[{"name":"Campus Hospital Kwame Nkrumah University of Science and Technology Kumasi Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Rolling","sequence":"additional","affiliation":[{"name":"Section\u00a0Tropical Medicine University Medical Center Hamburg\u2010Eppendorf Hamburg Germany"},{"name":"Clinical Research Group Bernhard Nocht Institute for Tropical Medicine Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Dekker","sequence":"additional","affiliation":[{"name":"Infectious Diseases Epidemiology Bernhard Nocht Institute for Tropical Medicine Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Adu\u2010Sarkodie","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Kwame Nkrumah University of Science and Technology Kumasi Ghana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. 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