{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T20:26:36Z","timestamp":1760646396028},"reference-count":48,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,10,19]],"date-time":"2015-10-19T00:00:00Z","timestamp":1445212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004417","name":"Global Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004417","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2015,12]]},"abstract":"Abstract<\/jats:title>Objective<\/jats:title>Data on feasibility and completion rates of isoniazid preventive therapy (IPT<\/jats:styled-content>) in HIV<\/jats:styled-content>\u2010infected patient in Asia are limited. Within a hospital\u2010based HIV<\/jats:styled-content> programme in Phnom Penh, Cambodia, we determined the proportion completing IPT<\/jats:styled-content> and reasons for non\u2010completion.<\/jats:p><\/jats:sec>Methods<\/jats:title>Retrospective cohort study using HIV<\/jats:styled-content>\/IPT<\/jats:styled-content> programme data, including all adults starting IPT<\/jats:styled-content> (300 mg\/day self\u2010administered for 24 weeks) from February 2011 to March 2013. All patients underwent symptom screening and further investigations as indicated. After ruling out tuberculosis (TB<\/jats:styled-content>), IPT<\/jats:styled-content> was started, with monthly follow\u2010up visits. As per national guideline, IPT<\/jats:styled-content> was only prescribed for ART<\/jats:styled-content>\u2010na\u00efve patients. IPT<\/jats:styled-content> completion was defined as taking IPT<\/jats:styled-content> for at least 22 of the planned 24 weeks. Stavudine\/lamivudine\/nevirapine was the preferential first\u2010line ART<\/jats:styled-content> regimen.<\/jats:p><\/jats:sec>Results<\/jats:title>Among 445 ART<\/jats:styled-content>\u2010na\u00efve patients starting IPT<\/jats:styled-content> (median age: 35 years (IQR<\/jats:styled-content>: 31\u201343), median CD<\/jats:styled-content>4 count 354 cells\/\u03bcl (IQR<\/jats:styled-content> 215\u2013545) and 288 (65%) were female), 214 (48%) started ART<\/jats:styled-content> after a median of 4 weeks (IQR<\/jats:styled-content> 2\u20136) on IPT<\/jats:styled-content> (\u2018concurrent ART<\/jats:styled-content>\u2019). Overall, 348 (78%) completed IPT<\/jats:styled-content>. Among individuals with concurrent ART<\/jats:styled-content>, the completion rate was 73% (157\/214). Those without concurrent ART<\/jats:styled-content> had a higher completion rate (83%; 191\/231; P<\/jats:italic> 0.017). The main reason for non\u2010completion with concurrent ART<\/jats:styled-content> was drug toxicity (mainly hepatotoxicity\/rash), occurring in 22% (48\/214). Without concurrent ART<\/jats:styled-content>, the main reason for non\u2010completion was loss to follow\u2010up (16\/231; 7%). Fourteen (3%) patients were diagnosed with TB<\/jats:styled-content> while on IPT<\/jats:styled-content>, of whom three had a positive TB<\/jats:styled-content> culture at baseline. An additional 14 TB<\/jats:styled-content> cases were diagnosed after IPT<\/jats:styled-content> completion; four were bacteriologically confirmed.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Although overall completion rates were acceptable, IPT<\/jats:styled-content> discontinuation due to drug toxicity was common in patients subsequently initiating ART<\/jats:styled-content>. Future studies should evaluate whether this relates to IPT<\/jats:styled-content>, ARV<\/jats:styled-content>s or both, and whether the increased toxicity would justify delaying IPT<\/jats:styled-content> initiation until stabilisation on ART<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.12609","type":"journal-article","created":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T21:50:42Z","timestamp":1443736242000},"page":"1823-1831","source":"Crossref","is-referenced-by-count":13,"title":["Implementation of isoniazid preventive therapy in an HIV<\/scp> clinic in Cambodia: high rates of discontinuation when combined with antiretroviral therapy"],"prefix":"10.1111","volume":"20","author":[{"given":"Johan","family":"van Griensven","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases Sihanouk Hospital Centre of HOPE Phnom Penh Cambodia"},{"name":"Department of Clinical Sciences Institute of Tropical Medicine Antwerp Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimcheng","family":"Choun","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Sihanouk Hospital Centre of HOPE Phnom Penh Cambodia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bopha","family":"Chim","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Sihanouk Hospital Centre of HOPE Phnom Penh Cambodia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sopheak","family":"Thai","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Sihanouk Hospital Centre of HOPE Phnom Penh Cambodia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalie","family":"Lorent","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Sihanouk Hospital Centre of HOPE Phnom Penh Cambodia"},{"name":"Department of Clinical Sciences Institute of Tropical Medicine Antwerp Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lutgarde","family":"Lynen","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Institute of Tropical Medicine Antwerp Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,10,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60409-6"},{"key":"e_1_2_7_3_1","volume-title":"WHO Three I's Meeting: Intensified Case Finding (ICF), Isoniazid Preventive Therapy (IPT) and TB Infection Control (IC) for People Living With HIV. 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