{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T20:29:24Z","timestamp":1790022564086,"version":"4.0.1"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Hepatitis E virus (<jats:styled-content style=\"fixed-case\">HEV<\/jats:styled-content>) is the cause of enterically transmitted non\u2010A, non\u2010C hepatitis (an infection that is particularly severe during pregnancy) in tropical and subtropical countries. As there are no published data concerning the prevalence of <jats:styled-content style=\"fixed-case\">HEV<\/jats:styled-content> antibodies in Benin, their presence was investigated in pregnant women undergoing routine <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> screening in a rural area in northern Benin and in pregnant women with acute non\u2010A, non\u2010C hepatitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 278 serum samples were collected from asymptomatic pregnant women in 2011 were tested for <jats:styled-content style=\"fixed-case\">HEV<\/jats:styled-content> and hepatitis A virus (<jats:styled-content style=\"fixed-case\">HAV<\/jats:styled-content>) antibodies, and the <jats:styled-content style=\"fixed-case\">HEV<\/jats:styled-content> IgM\u2010positive samples were further tested for <jats:styled-content style=\"fixed-case\">HEV<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>. A further seven samples of pregnant women with acute non\u2010A, non\u2010C hepatitis collected during episodes of acute hepatitis in 2005 were also analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 278 samples collected in 2011, 16.19% were positive for <jats:styled-content style=\"fixed-case\">HEV<\/jats:styled-content> IgG and 1.44% for <jats:styled-content style=\"fixed-case\">HEV<\/jats:styled-content> IgM (none positive for <jats:styled-content style=\"fixed-case\">HEV<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>), and 99.64% were positive for total <jats:styled-content style=\"fixed-case\">HAV<\/jats:styled-content> antibodies (none positive for <jats:styled-content style=\"fixed-case\">HAV<\/jats:styled-content> IgM). Six of the seven samples collected in 2005 were positive for <jats:styled-content style=\"fixed-case\">HEV<\/jats:styled-content> IgG and IgM, and two were also positive for <jats:styled-content style=\"fixed-case\">HEV<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The circulation of <jats:styled-content style=\"fixed-case\">HEV<\/jats:styled-content> infection is significant among pregnant women in Benin, in whom the consequences may be fatal.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.12632","type":"journal-article","created":{"date-parts":[[2015,11,2]],"date-time":"2015-11-02T16:36:19Z","timestamp":1446482179000},"page":"108-113","source":"Crossref","is-referenced-by-count":20,"title":["Epidemiology of hepatitis E virus infection during pregnancy in Benin"],"prefix":"10.1111","volume":"21","author":[{"given":"Massimo","family":"De Paschale","sequence":"first","affiliation":[{"name":"Microbiology Unit Hospital of Legnano Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Ceriani","sequence":"additional","affiliation":[{"name":"Microbiology Unit Hospital of Legnano Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Roman\u00f2","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences for Health University of Milan Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Cerulli","sequence":"additional","affiliation":[{"name":"Microbiology Unit Hospital of Legnano Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debora","family":"Cagnin","sequence":"additional","affiliation":[{"name":"Microbiology Unit Hospital of Legnano Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena","family":"Cavallari","sequence":"additional","affiliation":[{"name":"Microbiology Unit Hospital of Legnano Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Ndayake","sequence":"additional","affiliation":[{"name":"H\u00f4pital Saint Jean de Dieu Tangui\u00e9ta B\u00e9nin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieudonn\u00e9","family":"Zaongo","sequence":"additional","affiliation":[{"name":"H\u00f4pital Saint Jean de Dieu Tangui\u00e9ta B\u00e9nin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kouma","family":"Diombo","sequence":"additional","affiliation":[{"name":"H\u00f4pital Saint Jean de Dieu Tangui\u00e9ta B\u00e9nin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianbattista","family":"Priuli","sequence":"additional","affiliation":[{"name":"H\u00f4pital Saint Jean de Dieu Tangui\u00e9ta B\u00e9nin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Vigan\u00f2","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department Hospital of Legnano Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierangelo","family":"Clerici","sequence":"additional","affiliation":[{"name":"Microbiology Unit Hospital of Legnano Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,12]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"The Global Prevalence of Hepatitis E Virus Infection and Susceptibility: A Systematic Review","author":"Aggarwal R","year":"2010"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24674"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.25505"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61030-6"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00235-07"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268807008941"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.23526"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-14-308"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0033-1338111"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2010.06540.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7292(00)00264-2"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(81)90758-0"},{"key":"e_1_2_6_14_1","unstructured":"World Health Organization.Hepatitis E Fact sheet No 280 Updated July 2015. 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