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We included only articles where samples were genotyped by sequencing since to date it is the most accurate method to unambiguously identify all <jats:italic>E. granulosus<\/jats:italic> s. l. genotypes. Also, we report new <jats:italic>E. granulosus<\/jats:italic> s. l. samples from Argentina and Uruguay analysed by sequencing of cox1 gene.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In South America, five countries have cystic echinococcosis cases for which sequencing data are available: Argentina, Brazil, Chile, Peru and Uruguay, adding up 1534 cases. <jats:italic>E. granulosus<\/jats:italic> s. s. (G1) accounts for most of the global burden of human and livestock cases. Also, <jats:italic>E. canadensis<\/jats:italic> (G6) plays a significant role in human cystic echinococcosis. Likewise, worldwide analysis of human cases showed that 72.9% are caused by <jats:italic>E. granulosus<\/jats:italic> s. s. (G1) and 12.2% and 9.6% by <jats:italic>E. canadensis<\/jats:italic> G6 and G7, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:italic>E. granulosus<\/jats:italic> s. s. (G1) accounts for most of the global burden followed by <jats:italic>E. canadensis<\/jats:italic> (G6 and G7) in South America and worldwide. This information should be taken into account to suit local cystic echinococcosis control and prevention programmes according to each molecular epidemiological situation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.12647","type":"journal-article","created":{"date-parts":[[2015,11,26]],"date-time":"2015-11-26T15:40:59Z","timestamp":1448552459000},"page":"166-175","source":"Crossref","is-referenced-by-count":142,"title":["Cystic echinococcosis in South America: systematic review of species and genotypes of <i>Echinococcus granulosus sensu lato<\/i> in humans and natural domestic hosts"],"prefix":"10.1111","volume":"21","author":[{"given":"Marcela Alejandra","family":"Cucher","sequence":"first","affiliation":[{"name":"Instituto de Investigaciones en Microbiolog\u00eda y Parasitolog\u00eda M\u00e9dica (IMPaM) Universidad de Buenos Aires (UBA)\u2010Consejo Nacional de Investigaciones Cient\u00edficas y Tecnol\u00f3gicas (CONICET) Buenos Aires 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