{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:01:59Z","timestamp":1790802119923,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,7,11]],"date-time":"2016-07-11T00:00:00Z","timestamp":1468195200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004423","name":"World Health Organization","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004423","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the prevalence of hypoxaemia among under\u2010five children admitted to hospital with clinical severe pneumonia and to assess the performance to diagnose hypoxaemia of models based on clinical signs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a hospital\u2010based survey in a district hospital from Southern Mozambique.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 825 children were recruited after obtaining an informed consent. The prevalence of hypoxaemia on admission was 27.9%, and 19.8% of these children died (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> compared with non\u2010hypoxaemic children 3.22, 95% CI 1.98\u20135.21, <jats:italic>P<\/jats:italic> &lt; 0.001). The model with larger area under the <jats:styled-content style=\"fixed-case\">ROC<\/jats:styled-content> curve (<jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ROC<\/jats:styled-content>) to predict hypoxaemia included cyanosis or thoracoabdominal breathing or respiratory rate \u226570 breaths per minute. None of the models performed well when tested in different case scenarios of oxygen availability through mathematical modelling, with over 50% of hypoxaemic children not receiving oxygen even in favourable case scenarios.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Clinical signs alone or in combination are not suitable to diagnose hypoxaemia. The use of pulse oximeters should be strongly encouraged.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.12738","type":"journal-article","created":{"date-parts":[[2016,6,16]],"date-time":"2016-06-16T17:44:42Z","timestamp":1466099082000},"page":"1147-1156","source":"Crossref","is-referenced-by-count":19,"title":["Hypoxaemia in Mozambican children &lt;5 years of age admitted to hospital with clinical severe pneumonia: clinical features and performance of predictor models"],"prefix":"10.1111","volume":"21","author":[{"given":"Quique","family":"Bassat","sequence":"first","affiliation":[{"name":"ISGlobal Barcelona Centre of International Health Research Universitat de Barcelona Barcelona Spain"},{"name":"Centro de Investiga\u00e7\u00e3o em Sa\u00fade de Manhi\u00e7a Maputo Mozambique"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Lanaspa","sequence":"additional","affiliation":[{"name":"ISGlobal Barcelona Centre of International Health Research Universitat de 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