{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T12:46:13Z","timestamp":1770900373766,"version":"3.50.1"},"reference-count":50,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,7,26]],"date-time":"2016-07-26T00:00:00Z","timestamp":1469491200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To describe the prevalence of human rhinovirus (<jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content>) species in children hospitalised with pneumonia in Manhi\u00e7a, Mozambique, and the associations between <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content> species and demographic, clinical and laboratory features.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Nasopharyngeal aspirates were collected from children 0 to 10 years of age (<jats:italic>n<\/jats:italic> = 277) presenting to Manhi\u00e7a District Hospital with clinical pneumonia. Blood samples were collected for <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> and malaria testing, blood culture and full blood counts, and a chest X\u2010ray was performed. A panel of common respiratory viruses was investigated using two independent multiplex <jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> assays with primers specific for each virus and viral type. <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content> species and genotypes were identified by seminested <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> assays, sequencing and phylogenetic tree analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At least one respiratory virus was identified in 206 (74.4%) children hospitalised with clinical pneumonia. <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content> was the most common virus identified in both <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010infected (17 of 38, 44.7%) and <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010uninfected (74 of 237, 31.2%; <jats:italic>P<\/jats:italic> = 0.100) children. <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content>\u2010A was the most common <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content> species identified (47 of 275, 17.0%), followed by <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content>\u2010C (35\/275, 12.6%) and <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content>\u2010B (8\/275, 2.9%). Clinical presentation of the different <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content> species was similar and overlapping, with no particular species being associated with specific clinical features.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content>\u2010A and <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content>\u2010C were the most common respiratory viruses identified in children hospitalised with clinical pneumonia in Manhi\u00e7a. Clinical presentation of <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content>\u2010A and <jats:styled-content style=\"fixed-case\">RV<\/jats:styled-content>\u2010C was similar and overlapping.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.12743","type":"journal-article","created":{"date-parts":[[2016,6,29]],"date-time":"2016-06-29T11:07:39Z","timestamp":1467198459000},"page":"1171-1180","source":"Crossref","is-referenced-by-count":17,"title":["Rhinovirus species and clinical features in children hospitalised with pneumonia from Mozambique"],"prefix":"10.1111","volume":"21","author":[{"given":"Alicia A.","family":"Annamalay","sequence":"first","affiliation":[{"name":"School of Paediatrics and Child Health The University of Western Australia Perth WA Australia"},{"name":"Telethon Kids Institute The University of Western Australia Perth WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Lanaspa","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o em Sa\u00fade de Manhi\u00e7a Maputo Mozambique"},{"name":"ISGlobal Barcelona Centre for International Health Research Hospital Cl\u00ednic \u2013 Universitat de Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siew\u2010Kim","family":"Khoo","sequence":"additional","affiliation":[{"name":"School of Paediatrics and Child Health The University of Western Australia Perth WA Australia"},{"name":"Telethon Kids Institute The University of Western Australia Perth WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lola","family":"Madrid","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o em Sa\u00fade de Manhi\u00e7a Maputo Mozambique"},{"name":"ISGlobal Barcelona Centre for International Health Research Hospital Cl\u00ednic \u2013 Universitat de Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sozinho","family":"Ac\u00e1cio","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o em Sa\u00fade de Manhi\u00e7a Maputo Mozambique"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guicheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Paediatrics and Child Health The University of Western Australia Perth WA Australia"},{"name":"School of Public Health Curtin University Perth WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingrid A.","family":"Laing","sequence":"additional","affiliation":[{"name":"School of Paediatrics and Child Health The University of Western Australia Perth WA Australia"},{"name":"Telethon Kids Institute The University of Western Australia Perth WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Gern","sequence":"additional","affiliation":[{"name":"University of Wisconsin\u2010Madison Madison WI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack","family":"Goldblatt","sequence":"additional","affiliation":[{"name":"School of Paediatrics and Child Health The University of Western Australia Perth WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joelene","family":"Bizzintino","sequence":"additional","affiliation":[{"name":"School of Paediatrics and Child Health The University of Western Australia Perth WA Australia"},{"name":"Telethon Kids Institute The University of Western Australia Perth WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah","family":"Lehmann","sequence":"additional","affiliation":[{"name":"Telethon Kids Institute The University of Western Australia Perth WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter N.","family":"Le Sou\u00ebf","sequence":"additional","affiliation":[{"name":"School of Paediatrics and Child Health The University of Western Australia Perth WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quique","family":"Bassat","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o em Sa\u00fade de Manhi\u00e7a Maputo Mozambique"},{"name":"ISGlobal Barcelona Centre for International Health Research Hospital Cl\u00ednic \u2013 Universitat de Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,7,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60222-6"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00037-07"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-9-78"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e31826fd39b"},{"key":"e_1_2_6_6_1","first-page":"563","article-title":"Pathogenesis of rhinovirus common colds in human volunteers","volume":"79","author":"Douglas RG","year":"1970","journal-title":"Ann Otolaryngol"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1086\/605697"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1086\/508551"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.20689"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1086\/524312"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00092410"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.10.007"},{"key":"e_1_2_6_13_1","first-page":"85","article-title":"Human rhinovirus C associated with wheezing in hospitalised children in the Middle East","volume":"46","author":"Miller EK","year":"2009","journal-title":"J Clin Microbiol"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2009.05.009"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3156.2011.02811.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e3181f232fe"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-11-65"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.23251"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-012-1692-9"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00063198-200305000-00010"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0086448"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61459-6"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.24025"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e31815b4935"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1086\/426457"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2008.03.012"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0051491"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0060845"},{"key":"e_1_2_6_29_1","doi-asserted-by":"crossref","first-page":"e105","DOI":"10.1097\/INF.0b013e31827cd06f","article-title":"Viral etiology of acute respiratory infections in hospitalized and outpatient children in Buenos, Aires, Argentina","volume":"32","author":"Marcone DN","year":"2013","journal-title":"Pediatr Infect Dis J"},{"key":"e_1_2_6_30_1","first-page":"1","article-title":"Single, dual and multiple respiratory virus infections and risk of hospitalization and mortality","volume":"1","author":"Goka EA","year":"2014","journal-title":"Epidemiol Infect"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0023514"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/1824-7288-39-22"},{"key":"e_1_2_6_33_1","unstructured":"AlonsoPL Sa\u00fateF AponteJJet al.Manhi\u00e7a DSS Mozambique. Population and Health in Developing Countries.International Development Research Centre:Ottawa;2002."},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000966"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00674-08"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201202-0330OC"},{"key":"e_1_2_6_37_1","first-page":"353","article-title":"Standardized interpretation of paediatric chest radiographs for the diagnosis of pneumonia in epidemiological studies","volume":"83","author":"Cherian T","year":"2005","journal-title":"Bull World Health Organ"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201303-0498OC"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/fmu010"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir1070"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2012.04.008"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2000.105350"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1553-2712.2007.00034.x"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000143642.72480.53"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2014.06.004"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0004596"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-7-36"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-200202000-00013"},{"key":"e_1_2_6_49_1","first-page":"914","article-title":"Respiratory syncytial virus infection: denominator\u2010based studies in Indonesia, Mozambique, Nigeria and South Africa","volume":"82","author":"Robertson SE","year":"2004","journal-title":"Bull World Health Organ"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0110435"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.21665"}],"container-title":["Tropical Medicine &amp; International Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftmi.12743","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tmi.12743","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T13:54:00Z","timestamp":1696168440000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tmi.12743"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,26]]},"references-count":50,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["10.1111\/tmi.12743"],"URL":"https:\/\/doi.org\/10.1111\/tmi.12743","archive":["Portico"],"relation":{},"ISSN":["1360-2276","1365-3156"],"issn-type":[{"value":"1360-2276","type":"print"},{"value":"1365-3156","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,26]]}}}