{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T05:27:58Z","timestamp":1788413278317,"version":"build-2803163510"},"reference-count":46,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,7,22]],"date-time":"2016-07-22T00:00:00Z","timestamp":1469145600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2016,9]]},"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:title>\n \n As guidelines are evolving towards recommending starting antiretroviral therapy (\n ART<\/jats:styled-content>\n ) in all\n HIV<\/jats:styled-content>\n \u2010positive individuals irrespective of clinical and immunological status,\n HIV<\/jats:styled-content>\n programmes will be challenged to manage an increasingly diverse set of patient needs. To support global guideline recommendations for differentiated service delivery,\n WHO<\/jats:styled-content>\n developed consensus definitions for two distinct patient populations: patients presenting with advanced disease and patients who are stable on\n ART<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n An expert panel consisting of 73 respondents from 28 countries across all six\n WHO<\/jats:styled-content>\n regions supported the development of these definitions. The panel included clinicians, researchers, programme managers, technical advisors and patient group representatives.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Patients presenting with advanced disease at presentation to care were defined as\n CD<\/jats:styled-content>\n 4 count <200\n CD<\/jats:styled-content>\n 4 cells\/mm\n 3<\/jats:sup>\n or\n WHO<\/jats:styled-content>\n Stage\n III<\/jats:styled-content>\n &\n IV<\/jats:styled-content>\n defining illness. Patients stable on\n ART<\/jats:styled-content>\n were defined as those who were receiving\n ART<\/jats:styled-content>\n for at least 1 year with no adverse drug reactions requiring regular monitoring, no current illnesses or pregnancy, a good understanding of lifelong adherence, and evidence of treatment success. Treatment success was defined as two consecutive undetectable viral load measures or, in the absence of viral load monitoring, rising\n CD<\/jats:styled-content>\n 4 counts or\n CD<\/jats:styled-content>\n 4 counts above 200 cells\/mm\n 3<\/jats:sup>\n and an objective adherence measure.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Patients who are stable on\n ART<\/jats:styled-content>\n should be offered a less intensive care package that can lead to improved outcomes while saving resources, including less frequent clinic visits, out\u2010of\u2010clinic drug refills and reduced laboratory monitoring. This will allow for clinic resources to be directed towards reducing morbidity and mortality among patients presenting with advanced disease.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/tmi.12746","type":"journal-article","created":{"date-parts":[[2016,7,2]],"date-time":"2016-07-02T08:56:58Z","timestamp":1467449818000},"page":"1124-1130","source":"Crossref","is-referenced-by-count":61,"title":["Stable patients and patients with advanced disease: consensus definitions to support sustained scale up of antiretroviral therapy"],"prefix":"10.1111","volume":"21","author":[{"given":"Greer","family":"Waldrop","sequence":"first","affiliation":[{"name":"Department of HIV World Health Organization Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meg","family":"Doherty","sequence":"additional","affiliation":[{"name":"Department of HIV World Health Organization Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Vitoria","sequence":"additional","affiliation":[{"name":"Department of HIV World Health Organization Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Ford","sequence":"additional","affiliation":[{"name":"Department of HIV World Health Organization Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,7,22]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"UNAIDS.\u201c15 by 15\u201d. 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