{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T13:01:14Z","timestamp":1758632474929},"reference-count":27,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,8,31]],"date-time":"2016-08-31T00:00:00Z","timestamp":1472601600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>In 2010, the <jats:styled-content style=\"fixed-case\">WHO<\/jats:styled-content> issued 77 priority research questions (<jats:styled-content style=\"fixed-case\">PRQ<\/jats:styled-content>s) to address <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010associated <jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content>. Objective of the this study was to assess the impact of defining the research agenda in stimulating and directing research around priority research questions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used number and type of scientific publications as a proxy to quantitatively assess the impact of research agenda setting. We conducted 77 single systematic reviews \u2013 one for every <jats:styled-content style=\"fixed-case\">PRQ<\/jats:styled-content> \u2013 building 77 different search strategies using <jats:styled-content style=\"fixed-case\">PRQ<\/jats:styled-content>s\u2019 keywords. Multivariate logistic regression models were applied to assess the quantity and quality of research produced over time and accounting for selected covariates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In 2009\u20132015, <jats:styled-content style=\"fixed-case\">PRQ<\/jats:styled-content>s were addressed by 1631 publications (median: 11 studies published per <jats:styled-content style=\"fixed-case\">PRQ<\/jats:styled-content>, range 1\u201396). The most published area was \u2018Intensified <jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content> case finding\u2019 (median: 23 studies\/<jats:styled-content style=\"fixed-case\">PRQ<\/jats:styled-content>, range: 2\u201374). The majority (62.1%, <jats:italic>n<\/jats:italic> = 1013) were published as original studies, and more than half (58%, <jats:italic>n<\/jats:italic> = 585) were conducted in the African region. Original studies\u2019 publication increased over the study period (<jats:italic>P<\/jats:italic> trend = &lt;0.001). They focused more on the \u2018Intensified <jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content> case finding\u2019 (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> = 2.17, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.56\u20132.93) and \u2018Drug\u2010resistant <jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> infection\u2019 (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> = 2.12, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.47\u20133.06) areas than non\u2010original studies. Original studies were published in journals of lower impact factor and received a smaller number of citations than non\u2010original studies (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> = 0.54, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.42\u20100.69).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The generation of evidence to address <jats:styled-content style=\"fixed-case\">PRQ<\/jats:styled-content>s has increased over time particularly in selected fields. Setting a priority research agenda for <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010associated <jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content> might have positively influenced the direction and the conduct of research and contributed to the global response to such a major threat to health.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.12768","type":"journal-article","created":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T05:15:12Z","timestamp":1472706912000},"page":"1420-1427","source":"Crossref","is-referenced-by-count":9,"title":["Assessing the impact of defining a global priority research agenda to address <scp>HIV<\/scp>\u2010associated tuberculosis"],"prefix":"10.1111","volume":"21","author":[{"given":"Anna","family":"Odone","sequence":"first","affiliation":[{"name":"London School of Hygiene and Tropical Medicine London UK"},{"name":"Department of Biomedical, Biotechnological and Translational Sciences University of Parma Parma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Matteelli","sequence":"additional","affiliation":[{"name":"WHO Collaborating Centre for TB\/HIV and TB Elimination University of Brescia Brescia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Chiesa","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Biotechnological and Translational Sciences University of Parma Parma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Cella","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Biotechnological and Translational Sciences University of Parma Parma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Biotechnological and Translational Sciences University of Parma Parma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Pezzetti","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Biotechnological and Translational Sciences University of Parma Parma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Signorelli","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Biotechnological and Translational Sciences University of Parma Parma Italy"},{"name":"University Vita\u2010Salute San Raffaele Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haileyesus","family":"Getahun","sequence":"additional","affiliation":[{"name":"Global TB Programme World Health Organization Geneva Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,8,31]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.7326\/M14-2210"},{"key":"e_1_2_5_3_1","volume-title":"Global Tuberculosis Report 2015","author":"WHO","year":"2015"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.163.9.1009"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.7448\/IAS.19.1.20714"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0112017"},{"key":"e_1_2_5_7_1","first-page":"471","article-title":"The research agenda for improving health policy, systems performance, and service delivery for tuberculosis control: a WHO perspective","volume":"80","author":"Nunn P","year":"2002","journal-title":"Bull World Health Organ"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)60570-0"},{"key":"e_1_2_5_9_1","unstructured":"World Health Organization.Executive Board. 134th session. 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