{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T14:10:07Z","timestamp":1791641407351,"version":"4.3.4"},"reference-count":30,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,10,24]],"date-time":"2016-10-24T00:00:00Z","timestamp":1477267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002923","name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Autoantibodies cross\u2010reacting with the <jats:italic>\u03b2<\/jats:italic>1 adrenergic receptor (anti\u2010<jats:italic>\u03b2<\/jats:italic>1<jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content> and anti\u2010p2<jats:italic>\u03b2<\/jats:italic>) and cardiac myosin antigens (anti\u2010B13) have been related to the pathogenesis of chronic Chagas heart disease (<jats:styled-content style=\"fixed-case\">CCHD<\/jats:styled-content>). Studies exploring their levels in different stages are scarce. We aimed to evaluate the relationship of these autoantibodies with the clinical profile of chronic patients, especially regarding their classificatory accuracy in severe presentation with heart failure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>We conducted a cross\u2010sectional study of 155 <jats:italic>T. cruzi\u2010<\/jats:italic>seropositive patients and 26 age\u2010 and gender\u2010matched healthy controls. They were categorised in three stages of <jats:styled-content style=\"fixed-case\">CCHD<\/jats:styled-content>. Serum antibodies were measured by specific immunoassays. Symptomatic individuals showed increased levels of anti\u2010<jats:italic>\u03b2<\/jats:italic>1<jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content> and anti\u2010B13, while anti\u2010p2<jats:italic>\u03b2<\/jats:italic> antibodies were similar between groups. A composite logistic regression model including anti\u2010B13, anti\u2010<jats:italic>\u03b2<\/jats:italic>1<jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content> antibody levels and age was able to predict systolic heart failure yielding an area under the curve of 83% (sensitivity of 67% and specificity of 89%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In our study, anti\u2010<jats:italic>\u03b2<\/jats:italic>1<jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content> and anti\u2010B13 antibodies were higher in individuals with chronic Chagas heart disease stage <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>, mainly in those with dilated cardiomyopathy associated with systolic heart failure. Logistic regression analysis showed that both antibodies were good predictors of severe <jats:styled-content style=\"fixed-case\">CCHD<\/jats:styled-content>. As well as being involved in disease progression, anti\u2010<jats:italic>\u03b2<\/jats:italic>1<jats:styled-content style=\"fixed-case\">AR<\/jats:styled-content> and anti\u2010B13 antibodies may be used as a serum marker of poor prognosis in terms of heart compromise.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.12791","type":"journal-article","created":{"date-parts":[[2016,10,11]],"date-time":"2016-10-11T16:14:36Z","timestamp":1476202476000},"page":"1545-1551","source":"Crossref","is-referenced-by-count":5,"title":["Combined analysis of cross\u2010reacting antibodies anti\u2010<i>\u03b2<\/i>1<scp>AR<\/scp> and anti\u2010B13 in advanced stages of Chagas heart disease"],"prefix":"10.1111","volume":"21","author":[{"given":"Luz M.","family":"Rodeles","sequence":"first","affiliation":[{"name":"Laboratory of Immunological Techniques National University of Littoral Santa Fe Argentina"},{"name":"Internal Medicine Department National University of Littoral Santa Fe Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel H.","family":"Vicco","sequence":"additional","affiliation":[{"name":"Laboratory of Immunological Techniques National University of Littoral Santa Fe Argentina"},{"name":"Internal Medicine Department National University of Littoral Santa Fe Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iv\u00e1n A.","family":"Bontempi","sequence":"additional","affiliation":[{"name":"Laboratory of Immunological Techniques National University of Littoral Santa Fe Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvaro","family":"Siano","sequence":"additional","affiliation":[{"name":"Organic Chemistry Department National University of Littoral Santa Fe Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgina","family":"Tonarelli","sequence":"additional","affiliation":[{"name":"Organic Chemistry Department National University of Littoral Santa Fe Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar A.","family":"Bottasso","sequence":"additional","affiliation":[{"name":"Institute of Clinical and Experimental Immunology UNR\u2010CONICET Rosario Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Arias","sequence":"additional","affiliation":[{"name":"Human Physiology Department National University of Rosario Rosario Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iv\u00e1n S.","family":"Marcipar","sequence":"additional","affiliation":[{"name":"Laboratory of Immunological Techniques National University of Littoral Santa Fe Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,10,24]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"World Health Organization.Investing to overcome the global impact of neglected tropical diseases: third WHO report on neglected diseases. 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