{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T19:25:24Z","timestamp":1789932324038,"version":"4.0.1"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,12,28]],"date-time":"2016-12-28T00:00:00Z","timestamp":1482883200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006636","name":"Forskningsr\u00e5det om H\u00e4lsa, Arbetsliv och V\u00e4lf\u00e4rd","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006636","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2017,3]]},"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:title>\n \n To assess the role of point\u2010of\u2010care (PoC) assessment of C\u2010reactive protein (\n CRP<\/jats:styled-content>\n ) and white blood cell (\n WBC<\/jats:styled-content>\n ) count to identify bacterial illness in Tanzanian children with non\u2010severe non\u2010malarial fever.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n From the outpatient department of a district hospital in Tanzania, 428 patients between 3 months and 5 years of age who presented with fever and a negative malaria test were enrolled. All had a physical examination and bacterial cultures from blood and urine. Haemoglobin,\n CRP<\/jats:styled-content>\n and\n WBC<\/jats:styled-content>\n were measured by PoC devices.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Positive blood cultures were detected in 6\/428 (1.4%) children and urine cultures were positive in 24\/401 (6.0%). Mean\n WBC<\/jats:styled-content>\n was similar in children with or without bacterial illness (14.0 \u00d7 10\n 9<\/jats:sup>\n , 95%\n CI<\/jats:styled-content>\n 12.0\u201316.0 \u00d7 109\n vs<\/jats:italic>\n . 12.0 \u00d7 10\n 9<\/jats:sup>\n , 95%\n CI<\/jats:styled-content>\n 11.4\u201312.7 \u00d7 109), while mean\n CRP<\/jats:styled-content>\n was higher in children with bacterial illness (41.0 mg\/l, 95%\n CI<\/jats:styled-content>\n 28.3\u201353.6\n vs<\/jats:italic>\n . 23.8 mg\/l, 95%\n CI<\/jats:styled-content>\n 17.8\u201327.8). In\n ROC<\/jats:styled-content>\n analysis, the optimum cut\u2010off value for\n CRP<\/jats:styled-content>\n to identify bacterial illness was 19 mg\/l but with an area under the curve of only 0.62. Negative predictive values exceeded 80%, while positive predictive values were under 40%.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n WBC<\/jats:styled-content>\n and\n CRP<\/jats:styled-content>\n levels had limited value in identifying children with bacterial infections. The positive predictive values for both tests were too low to be used as single tools for treatment decisions.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/tmi.12823","type":"journal-article","created":{"date-parts":[[2016,12,9]],"date-time":"2016-12-09T14:54:16Z","timestamp":1481295256000},"page":"286-293","source":"Crossref","is-referenced-by-count":18,"title":["Point\u2010of\u2010care assessment of C\u2010reactive protein and white blood cell count to identify bacterial aetiologies in malaria\u2010negative paediatric fevers in Tanzania"],"prefix":"10.1111","volume":"22","author":[{"given":"Helena","family":"Hildenwall","sequence":"first","affiliation":[{"name":"Global Health, Health Systems and Policy Department of Public Health Sciences Karolinska Institutet Stockholm Sweden"},{"name":"Astrid Lindgren Children's Hospital Karolinska University Hospital Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florida","family":"Muro","sequence":"additional","affiliation":[{"name":"Kilimanjaro Christian Medical University College Moshi Tanzania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaqueline","family":"Jansson","sequence":"additional","affiliation":[{"name":"Global Health, Health Systems and Policy Department of Public Health Sciences Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Mtove","sequence":"additional","affiliation":[{"name":"Joint Malaria Programme St Augustine's Hospital Muheza Tanzania"},{"name":"National Institute for Medical Research Amani Centre Muheza Tanga Tanzania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugh","family":"Reyburn","sequence":"additional","affiliation":[{"name":"London School of Hygiene and Tropical Medicine London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Amos","sequence":"additional","affiliation":[{"name":"Joint Malaria Programme St Augustine's Hospital Muheza Tanzania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,12,28]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"Guidelines for the Treatment of Malaria","author":"WHO","year":"2010"},{"key":"e_1_2_7_3_1","volume-title":"T3: Test. 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