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Current control measures, in particular culling infected dogs, have not reduced<jats:styled-content style=\"fixed-case\">ZVL<\/jats:styled-content>incidence in humans. We evaluated the use of five systemic insecticides (spinosad, fluralaner, afoxolaner, sarolaner and moxidectin) currently used in dogs for other purposes (e.g. tick, flea control) in controlling<jats:styled-content style=\"fixed-case\">ZVL<\/jats:styled-content>transmission. The anti\u2010phlebotomine capacity of these compounds confirmed in experimental studies makes their use in<jats:styled-content style=\"fixed-case\">ZVL<\/jats:styled-content>control programmes very promising. 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