{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T14:54:41Z","timestamp":1783436081363,"version":"3.54.6"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,5,22]],"date-time":"2017-05-22T00:00:00Z","timestamp":1495411200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81560024"],"award-info":[{"award-number":["81560024"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81360085"],"award-info":[{"award-number":["81360085"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Diabetes mellitus is a common endocrinopathy in patients with <jats:italic>\u03b2<\/jats:italic>\u2010thalassaemia major (<jats:italic>\u03b2<\/jats:italic>\u2010<jats:styled-content style=\"fixed-case\">TM<\/jats:styled-content>), which is high prevalent in southern China. This study aimed to determine the cause and prevalence of glycaemic disorders in Chinese children with <jats:italic>\u03b2<\/jats:italic>\u2010<jats:styled-content style=\"fixed-case\">TM<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this prospective study, fasting glucose and insulin (<jats:styled-content style=\"fixed-case\">FINS<\/jats:styled-content>) levels were assessed in 267 <jats:italic>\u03b2<\/jats:italic>\u2010<jats:styled-content style=\"fixed-case\">TM<\/jats:styled-content> and 80 non\u2010<jats:styled-content style=\"fixed-case\">TM<\/jats:styled-content> control children. Homeostatic model assessment (<jats:styled-content style=\"fixed-case\">HOMA<\/jats:styled-content>) and the quantitative insulin sensitivity check index (<jats:styled-content style=\"fixed-case\">QUICKI<\/jats:styled-content>) were evaluated. Iron overload was assessed by serum ferritin (<jats:styled-content style=\"fixed-case\">SF<\/jats:styled-content>), total units of blood transfused and cardiac T2*.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic>\u03b2<\/jats:italic>\u2010TM had higher FPG (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), FINS (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.001) and <jats:styled-content style=\"fixed-case\">HOMA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05), but lower <jats:styled-content style=\"fixed-case\">QUICKI<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01) than those of controls. The impaired fasting glucose (<jats:styled-content style=\"fixed-case\">IFG<\/jats:styled-content>) was present in 30% of children, whereas 2% had diabetes. The prevalence of <jats:styled-content style=\"fixed-case\">IFG<\/jats:styled-content> in <jats:italic>\u03b2<\/jats:italic>\u2010<jats:styled-content style=\"fixed-case\">TM<\/jats:styled-content> group was higher in children aged &gt;10\u00a0years (OR 6.5; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 3.7\u201311.4; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), <jats:styled-content style=\"fixed-case\">SF<\/jats:styled-content> of &gt;2500\u00a0\u03bcg\/l (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 4.8; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 2.1\u201311.1; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01), serum <jats:styled-content style=\"fixed-case\">ALT<\/jats:styled-content> levels of &gt;50\u00a0IU\/l (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 2.1; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.2\u20133.7; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) and cardiac T2* of &lt;20\u00a0ms (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 3.3; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.7\u20136.6; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00. 01). The children on deferiprone (<jats:styled-content style=\"fixed-case\">DFP<\/jats:styled-content>) had a reduced incidence of glycaemic aberrations than those on other chelating agents (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 0.4; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.23\u20130.8; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our data suggest that <jats:styled-content style=\"fixed-case\">IFG<\/jats:styled-content> occurred in 30% of <jats:italic>\u03b2 <\/jats:italic><jats:styled-content style=\"fixed-case\">TM<\/jats:styled-content> children, perhaps due to insulin resistance secondary to iron overload. Deferiprone\u2010containing chelating agent may have a protective effect.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.12876","type":"journal-article","created":{"date-parts":[[2017,5,23]],"date-time":"2017-05-23T23:34:45Z","timestamp":1495582485000},"page":"716-724","source":"Crossref","is-referenced-by-count":12,"title":["Prevalence of diabetes mellitus in Chinese children with thalassaemia major"],"prefix":"10.1111","volume":"22","author":[{"given":"Yuzhen","family":"Liang","sequence":"first","affiliation":[{"name":"Second Affiliated Hospital of Guangxi Medical University Nanning Guangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rekha","family":"Bajoria","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Institute for Women's Health Haematology Unit University College Hospitals and Royal Free Hospital London 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