{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,19]],"date-time":"2023-11-19T09:27:10Z","timestamp":1700386030642},"reference-count":26,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,8,10]],"date-time":"2017-08-10T00:00:00Z","timestamp":1502323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe the cascade of care to <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> mother\u2010to\u2010child transmission (<jats:styled-content style=\"fixed-case\">PMTCT<\/jats:styled-content>) in a Rio de Janeiro reference paediatric clinic and evaluate the main factors possibly associated with <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> transmission.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data on antenatal care (ANC), perinatal and neonatal assistance to <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010infected and <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010exposed but uninfected children assisted in the clinic from 1996 to 2013 were collected. The cascade of care was graphically demonstrated, and possible factors associated with <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> infection were described using regression models for bivariate and multivariate analysis. We imputed missing values of explanatory variables for the final model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 989 children were included in the analysis: 211 were <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> and 778 <jats:styled-content style=\"fixed-case\">HEU<\/jats:styled-content>. Graphically, the <jats:styled-content style=\"fixed-case\">HIV PMTCT<\/jats:styled-content> cascade of care improved from 1996\/2000 to the later periods, but not from 2001\/2006 to 2007\/2013. The main factor independently associated with the <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> infection over time was breastfeeding. In the period 1996\/2000, the lack of antiretroviral use during labour was associated <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> transmission. While in 2001\/2007, other modes of delivery but elective Caesarean section, and lack of maternal antiretroviral use during ANC were associated with <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> transmission. In the last period, the main factor associated with transmission was the lack of maternal ANC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">HIV PMTCT<\/jats:styled-content> cascade improved over time, but <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> vertical transmission remains a problem, and better access to ANC is needed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.12925","type":"journal-article","created":{"date-parts":[[2017,7,14]],"date-time":"2017-07-14T06:58:42Z","timestamp":1500015522000},"page":"1266-1274","source":"Crossref","is-referenced-by-count":3,"title":["The cascade of care to prevent mother\u2010to\u2010child transmission in Rio de Janeiro, Brazil, 1996\u20132013: improving but still some way to go"],"prefix":"10.1111","volume":"22","author":[{"given":"Cristina Barroso","family":"Hofer","sequence":"first","affiliation":[{"name":"Institute of Social and Preventive Medicine Berne University Berne Switzerland"},{"name":"Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Egger","sequence":"additional","affiliation":[{"name":"Institute of Social and Preventive Medicine Berne University Berne Switzerland"},{"name":"School of Public Health and Family Medicine University of Cape Town Cape Town South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary\u2010Ann","family":"Davies","sequence":"additional","affiliation":[{"name":"School of Public Health and Family Medicine University of Cape Town Cape Town South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Cristina Cisne","family":"Frota","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo Hugo","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thalita Fernandes","family":"Abreu","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00facia Evangelista","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernardo Bastos","family":"Witthlin","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice Weber","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jana\u00edna Rivas","family":"Cordeiro","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia Pasqualini","family":"Lima","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivia","family":"Keiser","sequence":"additional","affiliation":[{"name":"Institute of Social and Preventive Medicine Berne University Berne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,8,10]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003510"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003510.pub3"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.socscimed.2009.05.034"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2012.05.026"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit374"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2013.06.021"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2012.10.862"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1086\/650005"},{"key":"e_1_2_5_10_1","unstructured":"Ministerio da Saude do Brasil.Protocolo cl\u00ednico e Diretrizes Terap\u00eauticas para Manejo da Infec\u00e7\u00e3o pelo HIV em Crian\u00e7as e Adolescentes2014. 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