{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T13:41:09Z","timestamp":1784641269905,"version":"3.55.0"},"reference-count":18,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,8,13]],"date-time":"2017-08-13T00:00:00Z","timestamp":1502582400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2017,10]]},"abstract":"Abstract<\/jats:title>Objective<\/jats:title>Cutaneous leishmaniasis (CL<\/jats:styled-content>) receives far less attention than visceral leishmaniasis. Nevertheless, CL<\/jats:styled-content> is predominantly caused by a unique species in Ethiopia (L.\u00a0aethiopica<\/jats:italic>), which is known to cause severe forms such as diffuse (DCL<\/jats:styled-content>) and mucocutaneous leishmaniasis (MCL<\/jats:styled-content>). We report on the number and type of CL<\/jats:styled-content> cases diagnosed, the clinical features, the treatments and treatment outcomes in North\u2010West Ethiopia.<\/jats:p><\/jats:sec>Methods<\/jats:title>This is a retrospective chart record analysis of CL<\/jats:styled-content> patients treated at the Leishmania Research and Treatment Center (LRTC<\/jats:styled-content>) of the University of Gondar, Ethiopia.<\/jats:p><\/jats:sec>Results<\/jats:title>From 178 CL<\/jats:styled-content> patients seen between January 2014 and December 2015, a total of 154 chart records were retrieved. These included 80 localised CL<\/jats:styled-content> (LCL<\/jats:styled-content>), 7 DCL<\/jats:styled-content> and 67 MCL<\/jats:styled-content>. The median age was 23\u00a0years; 71.4% were male. Most (n<\/jats:italic>\u00a0=\u00a0121, 78.6%) of the lesions were on the face. The median time since onset was 12\u00a0months (6\u201324\u00a0months), and 28.6% presented after a trial of traditional medicine. The treatment of all forms of CL<\/jats:styled-content> mainly consisted of 30\u00a0days of IM<\/jats:styled-content> antimonial injections. Of these, 51\/133 (38.3%) required treatment extension or change due to nonresponse. Three cases were treated with liposomal amphotericin B or miltefosine (two received the combination), of which two responded well.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>CL<\/jats:styled-content> was found to be complicated and difficult to treat. MCL<\/jats:styled-content> was common, and patients presented after long delays. There is an urgent need to look for better treatment options for CL<\/jats:styled-content> and improve access to care.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.12928","type":"journal-article","created":{"date-parts":[[2017,7,16]],"date-time":"2017-07-16T13:12:36Z","timestamp":1500210756000},"page":"1293-1301","source":"Crossref","is-referenced-by-count":52,"title":["Clinical features and treatment response of cutaneous leishmaniasis in North\u2010West Ethiopia"],"prefix":"10.1111","volume":"22","author":[{"given":"Helina","family":"Fikre","sequence":"first","affiliation":[{"name":"Leishmaniasis Research and Treatment Center University of Gondar Gondar Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rezika","family":"Mohammed","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Gondar Gondar Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saba","family":"Atinafu","sequence":"additional","affiliation":[{"name":"Leishmaniasis Research and Treatment Center University of Gondar Gondar Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"van Griensven","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Institute of Tropical Medicine Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ermias","family":"Diro","sequence":"additional","affiliation":[{"name":"Leishmaniasis Research and Treatment Center University of Gondar Gondar Ethiopia"},{"name":"Department of Internal Medicine University of Gondar Gondar Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(07)70209-8"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035671"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trstmh.2009.02.023"},{"key":"e_1_2_6_5_1","first-page":"205","article-title":"Leishmania major in an Egyptian patient manifested as diffuse cutaneous leishmaniasis","volume":"27","author":"Morsy TA","year":"1997","journal-title":"J Egypt Soc Parasitol"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0004495"},{"key":"e_1_2_6_7_1","author":"Ministry of Health E","journal-title":"Guideline for diagnosis, treatment & prevention of leishmaniasis in Ethiopia"},{"key":"e_1_2_6_8_1","unstructured":"Proceedings of the international consultative meeting on cutaneous leishmaniasis in Ethiopia"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002130"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trstmh.2012.02.006"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(78)90173-6"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.15-0033"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2013.01.022"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.4081\/gh.2014.27"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002196"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004360050529"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/160.1.104"},{"key":"e_1_2_6_18_1","first-page":"623","article-title":"Current status and perspectives of the immunotherapy of leishmaniasis","volume":"11","author":"El\u2010On J","year":"2009","journal-title":"Isr Med Assoc J"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00296"}],"container-title":["Tropical Medicine & International Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftmi.12928","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tmi.12928","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T08:13:09Z","timestamp":1695975189000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tmi.12928"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,13]]},"references-count":18,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["10.1111\/tmi.12928"],"URL":"https:\/\/doi.org\/10.1111\/tmi.12928","archive":["Portico"],"relation":{},"ISSN":["1360-2276","1365-3156"],"issn-type":[{"value":"1360-2276","type":"print"},{"value":"1365-3156","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,13]]}}}