{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T23:18:37Z","timestamp":1781306317865,"version":"3.54.1"},"reference-count":30,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,9,20]],"date-time":"2017-09-20T00:00:00Z","timestamp":1505865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>In a previous study performed by our group, <jats:italic>Strongyloides stercoralis<\/jats:italic> infection in patients with Chagas disease was associated with higher proportion of <jats:italic>Trypanosoma cruzi <\/jats:italic><jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> detection in peripheral blood. The aim of the study was to confirm this association in a larger cohort of patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cross\u2010sectional study of all patients with Chagas disease diagnosed from 2005 to 2015 during blood donation at the Catalan Blood Bank. Demographic data and <jats:italic>T. cruzi <\/jats:italic><jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> were collected. <jats:italic>S. stercoralis<\/jats:italic> infection diagnosis was based on a serological test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two hundred and two blood donors were included. <jats:italic>T. cruzi <\/jats:italic><jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> was positive in 72 (35.6%) patients, and <jats:italic>S. stercoralis<\/jats:italic> serology was positive in 22 (10.9%) patients. Patients with positive <jats:italic>S. stercoralis<\/jats:italic> serology had higher proportion of positive <jats:italic>T. cruzi <\/jats:italic><jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> than those with negative serology (54.5% <jats:italic>vs<\/jats:italic>. 33.3%, <jats:italic>P<\/jats:italic> = 0.050), and the difference increased when taking a serological index cut\u2010off of 2.5, which increases the specificity of the test to detect a confirmed strongyloidiasis (60% <jats:italic>vs<\/jats:italic>. 33%, <jats:italic>P<\/jats:italic> = 0.017).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with Chagas disease with positive <jats:italic>S. stercoralis<\/jats:italic> serology had higher proportion of positive <jats:italic>T. cruzi <\/jats:italic><jats:styled-content style=\"fixed-case\">RT<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> in peripheral blood than those with negative serology, which reflects the potential immunomodulatory effects of <jats:italic>S. stercoralis<\/jats:italic> in <jats:italic>T. cruzi<\/jats:italic> co\u2010infected patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.12970","type":"journal-article","created":{"date-parts":[[2017,9,4]],"date-time":"2017-09-04T15:26:37Z","timestamp":1504538797000},"page":"1436-1441","source":"Crossref","is-referenced-by-count":19,"title":["<i>Strongyloides stercoralis<\/i> infection increases the likelihood to detect <i>Trypanosoma cruzi <\/i><scp>DNA<\/scp> in peripheral blood in Chagas disease patients"],"prefix":"10.1111","volume":"22","author":[{"given":"Fernando","family":"Salvador","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases Vall d'Hebron University Hospital PROSICS Barcelona Universitat Aut\u00f2noma de Barcelona Barcelona 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