{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T08:33:16Z","timestamp":1777365196494,"version":"3.51.4"},"reference-count":50,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,11,20]],"date-time":"2017-11-20T00:00:00Z","timestamp":1511136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2017,12]]},"abstract":"Abstract<\/jats:title>Objectives<\/jats:title>To systematically review evidence on the prevalence and characteristics of hearing impairment among children and adults living with HIV<\/jats:styled-content> in low\u2010 and middle\u2010income countries (LMIC<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>Articles were identified up to January 2016 through searching four electronic databases. Epidemiological studies conducted in LMIC<\/jats:styled-content> that explored the association between HIV<\/jats:styled-content> status and hearing loss, with or without an HIV<\/jats:styled-content>\u2010uninfected comparison group, were eligible for inclusion. Results were screened and assessed for eligibility, and data were extracted by two reviewers, with discussion in the case of disagreement. Findings were narratively synthesised.<\/jats:p><\/jats:sec>Results<\/jats:title>The search identified 638 unique references, of which 21 studies were included in the review, including 3491 people with HIV<\/jats:styled-content> from 13 LMIC<\/jats:styled-content>. There was lack of consistency in the definition used for hearing loss, making comparability across studies difficult. Among children with HIV<\/jats:styled-content>, across the three studies that used a cut\u2010off of >15\u00a0dB in either ear, the prevalence of hearing loss ranged from 22 to 37%. Among the three studies that used >25\u00a0dB in either ear, the prevalence ranged from 32 to 39%. Among adults with HIV<\/jats:styled-content>, for the five studies that used a threshold of >25\u00a0dB for either ear, the prevalence ranged from 10 to 43%. The prevalence of hearing impairment was significantly higher among people with HIV<\/jats:styled-content> than in controls in eight of the ten studies that assessed this comparison. Conductive hearing loss was the most common type of hearing loss in children with HIV<\/jats:styled-content>, while sensorineural hearing loss was more common in adults with HIV<\/jats:styled-content>. There was a lack of evidence for an association between ART<\/jats:styled-content> use and hearing loss, although there was some suggestion that late stage of HIV<\/jats:styled-content> disease or low CD<\/jats:styled-content>4 count was related to hearing loss. There were concerns about the quality of the studies included in the review.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The current evidence is suggestive of a high prevalence of hearing loss among people living with HIV<\/jats:styled-content> compared to people without HIV<\/jats:styled-content>, or to WHO<\/jats:styled-content> estimates for the general population. More research is needed to better understand the aetiology of hearing loss in relation to HIV<\/jats:styled-content>, and whether screening for and treatment of hearing loss can be effectively integrated into HIV<\/jats:styled-content> treatment services needs further research.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.12993","type":"journal-article","created":{"date-parts":[[2017,10,27]],"date-time":"2017-10-27T16:42:38Z","timestamp":1509122558000},"page":"1493-1504","source":"Crossref","is-referenced-by-count":24,"title":["Is hearing impairment associated with HIV<\/scp>? 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