{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T11:31:34Z","timestamp":1788003094072,"version":"build-2784847793"},"reference-count":26,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,11,20]],"date-time":"2017-11-20T00:00:00Z","timestamp":1511136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To estimate the Brazilian direct and indirect costs of human visceral leishmaniasis (<jats:styled-content style=\"fixed-case\">VL<\/jats:styled-content>) in 2014.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cost\u2010of\u2010illness study on the Brazilian public health system and societal perspective.<jats:styled-content style=\"fixed-case\">VL<\/jats:styled-content>cases registered in the Notifiable Diseases Information System in the year of 2014 were considered. Direct medical costs regarding diagnostic, treatment and care provided to patients with<jats:styled-content style=\"fixed-case\">VL<\/jats:styled-content>were estimated through the top\u2010down approach. The indirect costs related to productivity loss due to premature mortality and morbidity were estimated by means of the human\u2010capital method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In 2014, 9895 suspected cases of<jats:styled-content style=\"fixed-case\">VL<\/jats:styled-content>were reported in the Notifiable Diseases Information System, and 3453 were later confirmed. There were 234 patients with Leishmania\u2010<jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>coinfection underwent a secondary prophylaxis. The total cost of<jats:styled-content style=\"fixed-case\">VL<\/jats:styled-content>in Brazil was<jats:styled-content style=\"fixed-case\">US<\/jats:styled-content>$ 14\u00a0190\u00a0701.50 (<jats:styled-content style=\"fixed-case\">US<\/jats:styled-content>$ 14\u00a0189\u00a0150.10 to 14\u00a0199\u00a0940.53) that varied according to the sensitivity analysis. The total of direct medical costs corresponded to<jats:styled-content style=\"fixed-case\">US<\/jats:styled-content>$ 1\u00a0873\u00a0681.96 (<jats:styled-content style=\"fixed-case\">US<\/jats:styled-content>$1\u00a0872\u00a0130.55 to 1\u00a0882\u00a0920.99), and the majority of costs was associated with hospitalisation (40%), followed by treatment (22%), and secondary prophylaxis (18%). Productivity loss corresponded to<jats:styled-content style=\"fixed-case\">US<\/jats:styled-content>$ 11\u00a0421\u00a0683.37 for premature mortality and<jats:styled-content style=\"fixed-case\">US<\/jats:styled-content>$ 895\u00a0336.18 for work absence due to hospitalisation by the illness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">VL<\/jats:styled-content>represents an expensive health problem for the Brazilian public health system and society, mainly because of its productivity loss due to premature mortality. Interventions to reduce<jats:styled-content style=\"fixed-case\">VL<\/jats:styled-content>lethality could have a great impact on decreasing the cost of illness.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.12994","type":"journal-article","created":{"date-parts":[[2017,10,27]],"date-time":"2017-10-27T19:46:36Z","timestamp":1509133596000},"page":"1579-1589","source":"Crossref","is-referenced-by-count":26,"title":["Cost of visceral leishmaniasis care in Brazil"],"prefix":"10.1111","volume":"22","author":[{"given":"Isis Polianna Silva Ferreira","family":"de Carvalho","sequence":"first","affiliation":[{"name":"Centre for Tropical Medicine University of Brasilia Brasilia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry Maia","family":"Peixoto","sequence":"additional","affiliation":[{"name":"Centre for Tropical Medicine University of Brasilia Brasilia Brazil"},{"name":"University Centre of Brasilia Brasilia Brazil"},{"name":"National Institute for Science and Technology for Health Technology Assessment (IATS\/CNPq) Porto Alegre RS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo Adolfo Sierra","family":"Romero","sequence":"additional","affiliation":[{"name":"Centre for Tropical Medicine University of Brasilia Brasilia Brazil"},{"name":"National Institute for Science and Technology for Health Technology Assessment (IATS\/CNPq) Porto Alegre RS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Regina Fernandes","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Centre for Tropical Medicine University of Brasilia Brasilia Brazil"},{"name":"National Institute for Science and Technology for Health Technology Assessment (IATS\/CNPq) Porto Alegre RS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,11,20]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"WHO.Leishmaniasis. 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