{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T07:53:07Z","timestamp":1770450787902,"version":"3.49.0"},"reference-count":24,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,11,22]],"date-time":"2017-11-22T00:00:00Z","timestamp":1511308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare the cost\u2010effectiveness of L\u2010AmB with that of Sb<jats:sup>V<\/jats:sup> and AmB\u2010D, for the treatment of mucocutaneous leishmaniasis in a hospital in north\u2010east Brazil.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We developed an economic model based on retrospective data of 73 hospitalised patients in 2006\u20132012, from hospital and public health system perspectives.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the economic model, 82.2% of patients who started treatment with L\u2010AmB had completed it after 2\u00a0months, <jats:italic>vs<\/jats:italic>. 22.0% for the Sb<jats:sup>V<\/jats:sup> and 19.9% for the AmB\u2010D groups. After 12\u00a0months of follow\u2010up, these proportions were 100% in the L\u2010AmB, 77.4% in the AmB\u2010D and 72.2% in the Sb<jats:sup>V<\/jats:sup> group. Markov chain analyses showed that the group that started therapy with Sb<jats:sup>V<\/jats:sup> had the lowest mean total cost (<jats:styled-content style=\"fixed-case\">US<\/jats:styled-content>$ 3782.38), followed by AmB\u2010D (<jats:styled-content style=\"fixed-case\">US<\/jats:styled-content>$ 5211.27) and L\u2010AmB (<jats:styled-content style=\"fixed-case\">US<\/jats:styled-content>$ 11\u00a0337.44). The incremental cost\u2010effectiveness ratio for L\u2010AmB was <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content>$ 18\u00a0816.23 against Sb<jats:sup>V<\/jats:sup> and <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content>$ 24\u00a0504.65 against AmB\u2010D. In the sensitivity analysis, the drug acquisition cost of L\u2010AmB significantly influenced the results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In the treatment of mucocutaneous leishmaniasis, L\u2010AmB is a cost\u2010effective alternative to Sb<jats:sup>V<\/jats:sup> and AmB\u2010D owing to its higher effectiveness, safety and shorter course.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.12996","type":"journal-article","created":{"date-parts":[[2017,10,27]],"date-time":"2017-10-27T20:22:38Z","timestamp":1509135758000},"page":"1569-1578","source":"Crossref","is-referenced-by-count":11,"title":["Cost\u2010effectiveness of liposomal amphotericin B in hospitalised patients with mucocutaneous leishmaniasis"],"prefix":"10.1111","volume":"22","author":[{"given":"S\u00f3stenes","family":"Mistro","sequence":"first","affiliation":[{"name":"Multidisciplinary Institute of Health Federal University of Bahia Vit\u00f3ria da Conquista Brazil"},{"name":"Program of Post\u2010Graduation in Medicine and Health Federal University of Bahia Salvador Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00e1rbara","family":"Gomes","sequence":"additional","affiliation":[{"name":"University Hospital \u201cProfessor Edgard Santos\u201d Federal University of Bahia Salvador Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorena","family":"Rosa","sequence":"additional","affiliation":[{"name":"Multidisciplinary Institute of Health Federal University of Bahia Vit\u00f3ria da Conquista Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ligia","family":"Miranda","sequence":"additional","affiliation":[{"name":"University Hospital \u201cProfessor Edgard Santos\u201d Federal University of Bahia Salvador Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianne","family":"Camargo","sequence":"additional","affiliation":[{"name":"Multidisciplinary Institute of Health Federal University of Bahia Vit\u00f3ria da Conquista Brazil"},{"name":"Program of Post\u2010Graduation in Medicine and Health Federal University of Bahia Salvador Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Badar\u00f3","sequence":"additional","affiliation":[{"name":"Program of Post\u2010Graduation in Medicine and Health Federal University of Bahia Salvador Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,11,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.15-0408"},{"key":"e_1_2_7_3_1","unstructured":"World Health Organization.Report of a meeting of the WHO Expert Committee on the Control of Leishmaniases. 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