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This is partly due to lack of well\u2010matched\n HUU<\/jats:styled-content>\n comparison groups needed to adjust for confounding factors.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n This was a prospective cohort study of infants enrolled at birth from a low\u2010risk midwife obstetric facility. At 12 months of age,\n HEU<\/jats:styled-content>\n and\n HUU<\/jats:styled-content>\n infant growth and neurodevelopmental outcomes were compared. Growth was evaluated as\n WHO<\/jats:styled-content>\n weight\u2010for\u2010age, length\u2010for\u2010age, weight\u2010for\u2010length and head\u2010circumference\u2010for\u2010age Z\u2010scores. Neurodevelopmental outcomes were evaluated using the Bayley scales of Infant Development\n III<\/jats:styled-content>\n (\n BSID<\/jats:styled-content>\n ) and Alarm Distress Baby Scale (\n ADBB<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Fifty\u2010eight\n HEU<\/jats:styled-content>\n and 38\n HUU<\/jats:styled-content>\n infants were evaluated at 11\u201314 months of age. Performance on the\n BSID<\/jats:styled-content>\n did not differ in any of the domains between\n HEU<\/jats:styled-content>\n and\n HUU<\/jats:styled-content>\n infants. The cognitive, language and motor scores were within the average range (\n US<\/jats:styled-content>\n standardised norms). Seven (12%)\n HEU<\/jats:styled-content>\n and 1 (2.6%)\n HUU<\/jats:styled-content>\n infant showed social withdrawal on the\n ADBB<\/jats:styled-content>\n (\n P<\/jats:italic>\n = 0.10), while 15 (26%)\n HEU<\/jats:styled-content>\n and 4 (11%)\n HUU<\/jats:styled-content>\n infants showed decreased vocalisation (\n P<\/jats:italic>\n = 0.06). There were no growth differences. Three\n HEU<\/jats:styled-content>\n and one\n HUU<\/jats:styled-content>\n infant had minor neurological signs, while eight\n HEU<\/jats:styled-content>\n and two\n HUU<\/jats:styled-content>\n infants had macrocephaly.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Although findings on the early neurodevelopmental outcome of\n HEU<\/jats:styled-content>\n infants are reassuring, minor differences in vocalisation and on neurological examination indicate a need for reassessment at a later age.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/tmi.13006","type":"journal-article","created":{"date-parts":[[2017,11,13]],"date-time":"2017-11-13T07:46:36Z","timestamp":1510559196000},"page":"69-78","source":"Crossref","is-referenced-by-count":40,"title":["Neurodevelopmental outcome of HIV\u2010exposed but uninfected infants in the Mother and Infants Health Study, Cape Town, South Africa"],"prefix":"10.1111","volume":"23","author":[{"given":"Priscilla 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Center Department of Pediatrics University of British Columbia Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henri\u00ebtte H.","family":"Saunders","sequence":"additional","affiliation":[{"name":"Department of Paediatrics & Child Health Faculty of Medicine and Health Sciences Stellenbosch University Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher D.","family":"Molteno","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of Cape Town Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Kruger","sequence":"additional","affiliation":[{"name":"Department of Paediatrics & Child Health Faculty of Medicine and Health Sciences Stellenbosch University Cape Town South 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