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Both requirements and definitions for eligibility and outcome criteria varied. Compliance with <jats:styled-content style=\"fixed-case\">CONSORT<\/jats:styled-content> requirements increased for studies published after the 2010 update. As for entry criteria, 94% of studies had a requirement for sex (74% of those enrolling also women excluded those who were pregnant or lactating), 69% for age (variable age ranges), 99% parasitological confirmation, 43% prior duration of illness (14% excluded cases with previous episodes), 46% defined the number, 28% the size and 13% the type of lesions (27% with restrictions as to their anatomical location). Follow\u2010up ranged 1\u201324\u00a0months, with 14% and 91% of studies, respectively, having defined initial and final cure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This review documents changes in reporting before and after the publication of the <jats:styled-content style=\"fixed-case\">CONSORT<\/jats:styled-content> statement. Lack of standardisation, compounded with the small number of trials relative to the magnitude of the disease in its multiple forms, and with the range of treatments tested explains why evidence to inform treatment guidelines is generally weak for <jats:styled-content style=\"fixed-case\">CL<\/jats:styled-content>. Adopting standardised methodologies will improve the quality and consistency of clinical trials, and ultimately yield better treatments for <jats:styled-content style=\"fixed-case\">CL<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.13048","type":"journal-article","created":{"date-parts":[[2018,3,10]],"date-time":"2018-03-10T04:42:35Z","timestamp":1520656955000},"page":"448-475","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Eligibility criteria and outcome measures adopted in clinical trials of treatments of cutaneous leishmaniasis: systematic literature review covering the period 1991\u20132015"],"prefix":"10.1111","volume":"23","author":[{"given":"Liliana","family":"L\u00f3pez\u2010Carvajal","sequence":"first","affiliation":[{"name":"Programa de Estudio y Control de Enfermedades Tropicales Universidad de Antioquia Medell\u00edn Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iv\u00e1n","family":"V\u00e9lez","sequence":"additional","affiliation":[{"name":"Programa de Estudio y Control de Enfermedades Tropicales Universidad de Antioquia Medell\u00edn Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Patricia","family":"Arbel\u00e1ez","sequence":"additional","affiliation":[{"name":"Universidad de Antioquia Medell\u00edn Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piero","family":"Olliaro","sequence":"additional","affiliation":[{"name":"UNICEF\/UNDP\/World Bank\/WHO Special Programme for Research and Training in Tropical Diseases Geneva Switzerland"},{"name":"Centre for Tropical Medicine and Global Health Nuffield Department of Medicine University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,4,17]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"Control of the Leishmaniasis","author":"World Health Organization (WHO)","year":"2010"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0004349"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035671"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-015-0114-z"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.12595_suppl"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(07)70209-8"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.298.16.1911"},{"key":"e_1_2_7_9_1","first-page":"CD004834","article-title":"Interventions for American cutaneous and mucocutaneous leishmaniasis","author":"Gonzalez U","year":"2009","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_10_1","unstructured":"World Health Organization (WHO).Working to overcome the global impact of neglected tropical diseases. 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