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This study aimed to determine and compare the prevalence and the genetic determinants of cefotaxime\u2010resistant and <jats:styled-content style=\"fixed-case\">ESBL<\/jats:styled-content>\u2010producing <jats:italic>Escherichia coli<\/jats:italic> in faecal isolates from workers and pigs at 100 farms in northern Vietnam.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Farmers were interviewed about antimicrobial usage in livestock. <jats:italic>Escherichia coli<\/jats:italic> isolated on MacConkey agar containing 2\u00a0mg\/l of cefotaxime (<jats:styled-content style=\"fixed-case\">CTX<\/jats:styled-content>) were tested for susceptibility to different cephalosporins by disc diffusion and screened for occurrence of <jats:styled-content style=\"fixed-case\">ESBL<\/jats:styled-content>\u2010encoding genes by <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Antimicrobial usage was widespread and included classes regarded of critical or high importance in human medicine. Dosages were 0.5\u20132 times higher than recommended, and antimicrobials were often administered right until slaughter. Prevalence of <jats:styled-content style=\"fixed-case\">CTX<\/jats:styled-content>\u2010resistant <jats:italic>E.\u00a0coli<\/jats:italic> was 86% in farm workers and 89% in pigs. In 76% of farms, <jats:styled-content style=\"fixed-case\">CTX<\/jats:styled-content>\u2010resistant <jats:italic>E.\u00a0coli<\/jats:italic> were shared by pigs and farm workers. <jats:styled-content style=\"fixed-case\">ESBL<\/jats:styled-content>\u2010producing <jats:italic>E.\u00a0coli<\/jats:italic> were detected from pigs and workers at 66 and 69 farms, respectively. The <jats:styled-content style=\"fixed-case\">ESBL<\/jats:styled-content> phenotype was mainly mediated by <jats:styled-content style=\"fixed-case\">CTX<\/jats:styled-content>\u2010M and to a lesser extent by <jats:styled-content style=\"fixed-case\">TEM<\/jats:styled-content>. Occurrence of <jats:italic>bla<\/jats:italic><jats:styled-content style=\"fixed-case\"><jats:sub>CTX<\/jats:sub><\/jats:styled-content><jats:sub>\u2010M<\/jats:sub> was similar in <jats:italic>E.\u00a0coli<\/jats:italic> from pigs (66.7%) and humans (68.5%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The high occurrence of <jats:styled-content style=\"fixed-case\">ESBL<\/jats:styled-content>\u2010producing <jats:italic>E.\u00a0coli<\/jats:italic> in pig farmers and pigs could present a risk for spillover of these bacteria from pig farms into the community. Genomic studies are needed to elucidate reservoirs and transmission routes of <jats:styled-content style=\"fixed-case\">ESBL<\/jats:styled-content>\u2010producing <jats:italic>E.\u00a0coli<\/jats:italic> at livestock farms.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.13054","type":"journal-article","created":{"date-parts":[[2018,3,25]],"date-time":"2018-03-25T15:15:01Z","timestamp":1521990901000},"page":"415-424","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Cephalosporin\u2010resistant <i>Escherichia coli<\/i> isolated from farm workers and pigs in northern Vietnam"],"prefix":"10.1111","volume":"23","author":[{"given":"Son T. 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