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M\u00f8ller og Hustru Chastine Mc-Kinney M\u00f8llers Fond til almene Formaal","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005747","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001731","name":"Danida Fellowship Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007438","name":"Familien Hede Nielsens Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007438","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2018,8]]},"abstract":"Abstract<\/jats:title>Objectives<\/jats:title>To describe the prevalence of CMV<\/jats:styled-content> in a cohort of HIV<\/jats:styled-content> infected individuals in Guinea\u2010Bissau, West Africa and to evaluate differences in patients\u2019 clinical characteristics associated with their CMV<\/jats:styled-content> status.<\/jats:p><\/jats:sec>Methods<\/jats:title>Newly diagnosed HIV<\/jats:styled-content> infected adults were invited to participate in this cross\u2010sectional study, from May until December 2015. Enrolled patients were interviewed and underwent a full physical examination focusing on CMV<\/jats:styled-content> disease manifestations. Blood samples were analysed for CMV<\/jats:styled-content> serology, QuantiFERON<\/jats:styled-content>\u2010CMV<\/jats:styled-content> response and CMV DNA<\/jats:styled-content>. Mortality follow\u2010up were registered for one year after inclusion.<\/jats:p><\/jats:sec>Results<\/jats:title>In total, 180 patients were enrolled. Anti\u2010CMV<\/jats:styled-content> IgG positivity was found in 100% (138\/138) and 2.8% (4\/138) were anti\u2010CMV<\/jats:styled-content> IgM positive. A positive QuantiFERON<\/jats:styled-content>\u2010CMV<\/jats:styled-content> response was found in 85.7% (60\/70) of the patients and 60.6% (83\/137) had CMV<\/jats:styled-content> viraemia. QuantiFERON<\/jats:styled-content>\u2010CMV<\/jats:styled-content> response and detectable CMV DNA<\/jats:styled-content> were associated with lower CD<\/jats:styled-content>4 cell count, older age and upper gastrointestinal complaints. During one year of follow\u2010up, the IRR<\/jats:styled-content> for death among CMV DNA<\/jats:styled-content> positive patients was 1.5 (P<\/jats:italic> = 0.5).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>CMV<\/jats:styled-content> coinfection was detected among all enrolled patients and CMV<\/jats:styled-content> viraemia was highly prevalent. Only age and upper gastrointestinal complaints were associated with the patients\u2019 CMV<\/jats:styled-content> status.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.13082","type":"journal-article","created":{"date-parts":[[2018,5,31]],"date-time":"2018-05-31T13:39:15Z","timestamp":1527773955000},"page":"896-904","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Prevalence and clinical characteristics of CMV coinfection among HIV infected individuals in Guinea\u2010Bissau: a cross\u2010sectional study"],"prefix":"10.1111","volume":"23","author":[{"given":"Helene L.","family":"Gr\u00f8nborg","sequence":"first","affiliation":[{"name":"GloHAU Department of Public Health Aarhus University Aarhus Denmark"},{"name":"Bandim Health Project Indepth Network Bissau Guinea\u2010Bissau"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanne","family":"Jespersen","sequence":"additional","affiliation":[{"name":"Bandim Health Project Indepth Network Bissau Guinea\u2010Bissau"},{"name":"Department of Infectious Diseases Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johanne H.","family":"Egedal","sequence":"additional","affiliation":[{"name":"Institute of Biomedicine Aarhus University Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faustino G.","family":"Correia","sequence":"additional","affiliation":[{"name":"Bandim Health Project Indepth Network Bissau Guinea\u2010Bissau"},{"name":"National HIV Programme Ministry of Health Bissau Guinea\u2010Bissau"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Candida","family":"Medina","sequence":"additional","affiliation":[{"name":"National HIV Programme Ministry of Health Bissau Guinea\u2010Bissau"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Krarup","sequence":"additional","affiliation":[{"name":"Section of Molecular Diagnostics Clinical Biochemistry Aalborg University Hospital Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo L.","family":"H\u00f8nge","sequence":"additional","affiliation":[{"name":"Bandim Health Project Indepth Network Bissau Guinea\u2010Bissau"},{"name":"National HIV Programme Ministry of Health Bissau Guinea\u2010Bissau"},{"name":"Department of Clinical Immunology Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Wejse","sequence":"additional","affiliation":[{"name":"GloHAU Department of Public Health Aarhus University Aarhus Denmark"},{"name":"Bandim Health Project Indepth Network Bissau Guinea\u2010Bissau"},{"name":"Department of Infectious Diseases Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the Bissau HIV Cohort Study Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,6,19]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"UNAIDS.Statistics 2015. 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