{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T21:43:08Z","timestamp":1773697388004,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,7,11]],"date-time":"2018-07-11T00:00:00Z","timestamp":1531267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["FAPESP 2015\/09080\u20102"],"award-info":[{"award-number":["FAPESP 2015\/09080\u20102"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>There is a clear need for new strategies of leishmaniasis treatment. This work was conducted to evaluate the efficacy of the co\u2010administration of tamoxifen and meglumine antimoniate (Sb<jats:sup>V<\/jats:sup>) in a phase <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> pilot clinical trial in localised cutaneous leishmaniasis patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A randomised controlled pilot clinical trial was conducted to evaluate the efficacy and safety of oral (40 mg\/day for 20 days) or topical tamoxifen (0.1% tamoxifen citrate for 20 days) combined with meglumine antimoniate (20 mg Sb<jats:sup>V<\/jats:sup>\/kg\/day for 20 days) <jats:italic>vs<\/jats:italic>. a standard Sb<jats:sup>V<\/jats:sup> protocol (20 mg\/kg\/day for 20 days) for the treatment of cutaneous leishmaniasis. Primary outcome was complete epithelisation of the lesion 6 months after the end of treatment. Secondary outcomes were lesion healing 2 months after the end of treatment and frequency and severity of adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 38 subjects were included in the trial, 15 were treated with standard Sb<jats:sup>V<\/jats:sup> and 23 with the combination of tamoxifen and Sb<jats:sup>V<\/jats:sup>. Of the patients treated with the co\u2010administration scheme, 12 received tamoxifen orally and 11 were treated with topical tamoxifen. Tamoxifen administered by the oral or topical routes was well tolerated. Cure rates 6 months after the end of treatment per intention to treat were 40% in the group treated with the standard Sb<jats:sup>V<\/jats:sup> scheme, and 36.4% and 58%, respectively, for groups treated with Sb<jats:sup>V<\/jats:sup> plus topical or oral tamoxifen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In the doses and schemes used in this study, co\u2010administration of oral tamoxifen and Sb<jats:sup>V<\/jats:sup> resulted in higher cure rates in comparison with the standard scheme of treatment, although not to statistically significant levels.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.13119","type":"journal-article","created":{"date-parts":[[2018,6,20]],"date-time":"2018-06-20T20:49:50Z","timestamp":1529527790000},"page":"936-942","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Tamoxifen and meglumine antimoniate combined therapy in cutaneous leishmaniasis patients: a randomised trial"],"prefix":"10.1111","volume":"23","author":[{"given":"Paulo R. L.","family":"Machado","sequence":"first","affiliation":[{"name":"Servi\u00e7o de Imunologia Hospital Universit\u00e1rio Prof. Edgar Santos Universidade Federal da Bahia Salvador Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camila S.","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Imunologia Hospital Universit\u00e1rio Prof. Edgar Santos Universidade Federal da Bahia Salvador Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaqueline","family":"Fran\u00e7a\u2010Costa","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Imunologia Hospital Universit\u00e1rio Prof. Edgar Santos Universidade Federal da Bahia Salvador Brazil"},{"name":"Instituto Gon\u00e7alo Moniz Funda\u00e7\u00e3o Oswaldo Cruz, Fiocruz\u2010BA Salvador\u2010BA Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayra E.F.","family":"Dourado","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Imunologia Hospital Universit\u00e1rio Prof. Edgar Santos Universidade Federal da Bahia Salvador Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristiana T.","family":"Trinconi","sequence":"additional","affiliation":[{"name":"Departamento de Parasitologia Universidade de S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenicer K. U.","family":"Yokoyama\u2010Yasunaka","sequence":"additional","affiliation":[{"name":"Departamento de Parasitologia Universidade de S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hayna","family":"Malta\u2010Santos","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Imunologia Hospital Universit\u00e1rio Prof. Edgar Santos Universidade Federal da Bahia Salvador Brazil"},{"name":"Instituto Gon\u00e7alo Moniz Funda\u00e7\u00e3o Oswaldo Cruz, Fiocruz\u2010BA Salvador\u2010BA Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val\u00e9ria M.","family":"Borges","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Imunologia Hospital Universit\u00e1rio Prof. Edgar Santos Universidade Federal da Bahia Salvador Brazil"},{"name":"Instituto Gon\u00e7alo Moniz Funda\u00e7\u00e3o Oswaldo Cruz, Fiocruz\u2010BA Salvador\u2010BA Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edgar M.","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Imunologia Hospital Universit\u00e1rio Prof. Edgar Santos Universidade Federal da Bahia Salvador Brazil"},{"name":"Instituto Gon\u00e7alo Moniz Funda\u00e7\u00e3o Oswaldo Cruz, Fiocruz\u2010BA Salvador\u2010BA Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia R. B.","family":"Uliana","sequence":"additional","affiliation":[{"name":"Departamento de Parasitologia Universidade de S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,7,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035671"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0004137"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.41.7.3126-3132.2003"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3156.2001.00778.x"},{"key":"e_1_2_6_6_1","unstructured":"WHO.Control of the leishmaniasis: report of a meeting of the World Health Organization Expert Committee on the Control of Leishmaniases. Technical report.Geneva:WHO;2010. 22\u201026 March 2010. Contract No.: 949."},{"key":"e_1_2_6_7_1","unstructured":"Brasil.Manual de vigil\u00e2ncia da leishmaniose tegumentar\/Manual for surveillance of cutaneous leishmaniasis. Minist\u00e9rio da Sa\u00fade Secretaria de Vigil\u00e2ncia em Sa\u00fade Departamento de Vigil\u00e2ncia das Doen\u00e7as Transmiss\u00edveis Bras\u00edlia; Minist\u00e9rio da Sa\u00fade;2017189 p Livro ilus tab. 2017."},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000912"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2011.10-0155"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0365-05962011000600005"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000249"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkn509"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182017000130"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-009-0983-1"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-4296(03)00031-6"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2011.05.009"},{"key":"e_1_2_6_17_1","first-page":"4837","article-title":"Distribution of tamoxifen and its metabolites in rat and human tissues during steady\u2010state treatment","volume":"51","author":"Lien EA","year":"1991","journal-title":"Can Res"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.4103\/0976-0105.177703"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-03-0538"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2007.43"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2010.192"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0000000000000492"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkm219"}],"container-title":["Tropical Medicine &amp; International Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftmi.13119","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tmi.13119","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T21:17:08Z","timestamp":1694985428000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tmi.13119"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,11]]},"references-count":22,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["10.1111\/tmi.13119"],"URL":"https:\/\/doi.org\/10.1111\/tmi.13119","archive":["Portico"],"relation":{},"ISSN":["1360-2276","1365-3156"],"issn-type":[{"value":"1360-2276","type":"print"},{"value":"1365-3156","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,11]]},"assertion":[{"value":"2018-07-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}