{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T11:06:53Z","timestamp":1784977613184,"version":"3.55.0"},"reference-count":19,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,8,14]],"date-time":"2018-08-14T00:00:00Z","timestamp":1534204800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["405407\/2016\u20105"],"award-info":[{"award-number":["405407\/2016\u20105"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the antimony (Sb) in plasma of patients who underwent a standardised meglumine antimoniate (<jats:styled-content style=\"fixed-case\">MA<\/jats:styled-content>) intralesional infiltration protocol for cutaneous leishmaniasis treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The level of Sb in plasma was determined by atomic absorption spectroscopy, before and 1, 2, 4 and 6 hours after the first intralesional infiltration of <jats:styled-content style=\"fixed-case\">MA<\/jats:styled-content> to determine the parameters peak concentrations (<jats:italic>C<\/jats:italic><jats:sub>1 h<\/jats:sub>)<jats:sub>,<\/jats:sub> area under curve of drug concentration in plasma from zero to 6 h (<jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content><jats:sub>0\u20106 h<\/jats:sub>) and elimination half\u2010life (<jats:italic>t<\/jats:italic>\u00bd) of Sb. Blood samples were also collected weekly during the treatment period, always before infiltration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fourteen patients underwent <jats:styled-content style=\"fixed-case\">MA<\/jats:styled-content> intralesional infiltration with doses ranging from 0.8 to 9 mg Sb\/kg at the first infiltration. The <jats:italic>C<\/jats:italic><jats:sub>1 h<\/jats:sub> ranged from 3850 to 47 095 mg \u00d7 h\/L and was the highest concentration obtained for 11 of 14 patients after the first intralesional infiltration of <jats:styled-content style=\"fixed-case\">MA<\/jats:styled-content>. A rapid initial phase of distribution lasting up to 4 h (2.6 \u00b1 0.34 h) was followed by a slower elimination phase. Total skin lesion area, <jats:italic>C<\/jats:italic><jats:sub>1 h<\/jats:sub> and <jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content><jats:sub>(0\u20106 h)<\/jats:sub> were related to the dose of Sb infiltered (<jats:italic>P<\/jats:italic> &lt; 0.05). Plasma Sb in samples collected weekly before the infiltration revealed antimony concentrations below the quantification limit (15.0 \u03bcg Sb\/l) during the treatment period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Sb is quickly absorbed and eliminated after intralesional administration of <jats:styled-content style=\"fixed-case\">MA<\/jats:styled-content>, in a pattern similar to that reported with the Sb systemic administration. Using a therapeutic schedule limited to weekly intralesional infiltration of doses &lt;10 mg Sb\/kg does not result in plasma Sb accumulation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.13130","type":"journal-article","created":{"date-parts":[[2018,7,27]],"date-time":"2018-07-27T16:35:28Z","timestamp":1532709328000},"page":"1110-1117","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Plasma antimony determination during cutaneous leishmaniasis treatment with intralesional infiltration of meglumine antimoniate"],"prefix":"10.1111","volume":"23","author":[{"given":"Marta Gontijo","family":"de Aguiar","sequence":"first","affiliation":[{"name":"Departamento de Produtos Farmac\u00eauticos Faculdade de Farm\u00e1cia Universidade Federal de Minas Gerais Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Eduardo","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Departamento de Produtos Farmac\u00eauticos Faculdade de Farm\u00e1cia Universidade Federal de Minas Gerais Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirna d'Auriol","family":"Souza","sequence":"additional","affiliation":[{"name":"Departamento de An\u00e1lises Cl\u00ednicas e Toxicol\u00f3gicas Faculdade de Farm\u00e1cia Universidade Federal de Minas Gerais Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosiana Estef\u00e1ne","family":"de Silva","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz\u2010Fiocruz Instituto Ren\u00e9 Rachou Centro de Refer\u00eancia em Leishmanioses Pesquisa Cl\u00ednica e Pol\u00edticas P\u00fablicas em Doen\u00e7as Infecto\u2010Parasit\u00e1rias Belo Horizonte MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josianne Nicacio","family":"Silveira","sequence":"additional","affiliation":[{"name":"Departamento de An\u00e1lises Cl\u00ednicas e Toxicol\u00f3gicas Faculdade de Farm\u00e1cia Universidade Federal de Minas Gerais Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gl\u00e1ucia","family":"Cota","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz\u2010Fiocruz Instituto Ren\u00e9 Rachou Centro de Refer\u00eancia em Leishmanioses Pesquisa Cl\u00ednica e Pol\u00edticas P\u00fablicas em Doen\u00e7as Infecto\u2010Parasit\u00e1rias Belo Horizonte MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,8,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.11120.1"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-017-0570-0"},{"key":"e_1_2_7_4_1","unstructured":"WHO.World Health Organization Map Production: Control of Neglected Tropical Diseases (NTD) World Health Organization. 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