{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T12:54:22Z","timestamp":1788526462137,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,9,10]],"date-time":"2018-09-10T00:00:00Z","timestamp":1536537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To identify the clinical and demographic characteristics of <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010positive and <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010negative women infected by multiple <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> types.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>1399 women participated in the study (240 <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010positive and 1159 <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010negative women). Samples were provided for Pap tests and for <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> detection and typing by <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>. Data were collected on <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> infection, frequency of multiple infection, and <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> type distribution. Odds ratios were reported from logistic regression models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010negative women, <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010positive women had higher frequencies of cervical abnormality (30% <jats:italic>vs<\/jats:italic>. 20.8%), higher <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> prevalence (68.3% <jats:italic>vs<\/jats:italic>. 51.3%) and were more commonly infected with multiple <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> types (78.7% <jats:italic>vs<\/jats:italic>. 44.3%). <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>\u201016 was the most common type detected in the study population, with other types showing variable associations with <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> status. Positive associations were observed between infection by multiple <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> types and <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> status, cervical abnormality and having had more than three pregnancies. The odds of multiple infection by <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> types were higher in <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010positive women who used an intrauterine device, who had a history of abortions and who had <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> viral loads &gt;100 000 copies\/ml, whilst the odds were lower in women with &gt;500 <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4 cells\/mm<jats:sup>3<\/jats:sup>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> immunosuppression favours infection by multiple high\u2010risk <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> types, mainly in women affected by low\u2010grade squamous intraepithelial lesions. Antiretroviral therapy had no effect on infection by multiple <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> types. Risk factors related to progressive damage to the cervix were positively associated with infection by multiple <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> types in women living with <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.13142","type":"journal-article","created":{"date-parts":[[2018,8,22]],"date-time":"2018-08-22T16:37:08Z","timestamp":1534955828000},"page":"1259-1268","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Association of HIV status with infection by multiple HPV types"],"prefix":"10.1111","volume":"23","author":[{"given":"Milena","family":"Camargo","sequence":"first","affiliation":[{"name":"Molecular Biology and Immunology Department Fundaci\u00f3n Instituto de Inmunolog\u00eda de Colombia Bogot\u00e1 DC Colombia"},{"name":"PhD Program in Biomedical and Biological Sciences School of Medicine and Health Sciences Universidad del Rosario Bogot\u00e1 DC Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Del R\u00edo\u2010Ospina","sequence":"additional","affiliation":[{"name":"Molecular Biology and Immunology Department Fundaci\u00f3n Instituto de Inmunolog\u00eda de Colombia Bogot\u00e1 DC Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara Cecilia","family":"Soto\u2010De Le\u00f3n","sequence":"additional","affiliation":[{"name":"Molecular Biology and Immunology Department Fundaci\u00f3n Instituto de Inmunolog\u00eda de Colombia Bogot\u00e1 DC Colombia"},{"name":"Universidad de Ciencias Aplicadas y Ambientales Bogot\u00e1 DC Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Molecular Biology and Immunology Department Fundaci\u00f3n Instituto de Inmunolog\u00eda de Colombia Bogot\u00e1 DC Colombia"},{"name":"Medical School Universidad Nacional de Colombia Bogot\u00e1 DC Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea Clemencia","family":"Pineda\u2010Pe\u00f1a","sequence":"additional","affiliation":[{"name":"Molecular Biology and Immunology Department Fundaci\u00f3n Instituto de Inmunolog\u00eda de Colombia Bogot\u00e1 DC Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Otto","family":"Sussmann","sequence":"additional","affiliation":[{"name":"Asistencia Cient\u00edfica de Alta Complejidad S.A.S. 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