{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T20:26:38Z","timestamp":1793219198892,"version":"4.5.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,11,8]],"date-time":"2018-11-08T00:00:00Z","timestamp":1541635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Intestinal tuberculosis (ITB) remains prevalent and a big health hazard in China. The aim of this study was to retrospectively analyse its clinico\u2010pathological features.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective study of 85 consecutive ITB patients in two tertiary hospitals in East China. Relevant clinical, laboratory examination, radiological, endoscopic and histopathological features of ITB were recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean age was 37.3\u00a0\u00b1\u00a016.0\u00a0years; 56 patients (65.9%) were male. 67.1% had ITB secondary to pulmonary tuberculosis. The overall median length of hospital stay was 28\u00a0days and was significantly longer in patients with intestinal complications (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.003) and malnutrition (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.042). Abdominal pain (88.2%) and weight loss (75.3%) were the commonest symptoms. The positive rate of the purified protein derivative (PPD) test was 88.2%; of the T\u2010spot, 85.7%. Histopathology revealed caseating granuloma in 70.6% and caseating necrosis in 24.7% of patients. The most commonly affected sites were the ileocecal valve (56, 65.9%), terminal ileum (40, 47.1%) and caecum (33, 38.8%). Only 17 (20%) patients were initially diagnosed as ITB, the other 68 patients were misdiagnosed. Six patients with caecum tuberculosis were misdiagnosed as appendicitis, four of whom had improper surgical procedures followed by post\u2010operative intestinal fistulas; two died due to MODS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Diagnosis of ITB is often misdirected and delayed, which may lead to inappropriate treatment and high mortality. High diagnostic suspicion is necessary for patients with unexplained abdominal complaints. Diagnosis is not easy but could benefit coexisting pulmonary tuberculosis, T\u2010spot, CT imaging, colonoscopy, pathological features, acid\u2010fast bacilli and response to anti\u2010tuberculosis therapy (ATT).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/tmi.13169","type":"journal-article","created":{"date-parts":[[2018,10,19]],"date-time":"2018-10-19T02:03:13Z","timestamp":1539914593000},"page":"81-90","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Intestinal tuberculosis: clinico\u2010pathological profile and the importance of a high degree of suspicion"],"prefix":"10.1111","volume":"24","author":[{"given":"Wei","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of General Surgery Jinling Hospital Medical School of Nanjing University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoyi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of General Surgery Shanghai Ninth People's Hospital Shanghai JiaoTong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yousheng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of General Surgery Shanghai Ninth People's Hospital Shanghai JiaoTong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of General Surgery Jinling Hospital Medical School of Nanjing University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieshou","family":"Li","sequence":"additional","affiliation":[{"name":"Department of General Surgery Jinling Hospital Medical School of Nanjing University Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,8]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"003","article-title":"Global epidemiology of tuberculosis","volume":"34","author":"Maher D","year":"2013","journal-title":"Lancet"},{"key":"e_1_2_7_3_1","first-page":"989","article-title":"Tuberculosis of the gastrointestinal tract and peritoneum","volume":"88","author":"Marshall JB","year":"2000","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.5009\/gnl15439"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000000514"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.53.1862"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1703.100919"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.01599.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-015-1325-x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2008.162"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2002.05686.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(02)00788-2"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0455.2002.430510.x"},{"issue":"2","key":"e_1_2_7_14_1","article-title":"Global tuberculosis report 2017","volume":"6","author":"World Health Organization","year":"2017","journal-title":"Australas Med J"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.4103\/0366-6999.182840"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-011-1219-3"},{"key":"e_1_2_7_17_1","first-page":"264","article-title":"Intestinal tuberculosis in a regional hospital in Hong Kong: a 10\u2010year experience","volume":"12","author":"Leung VK","year":"2006","journal-title":"Hong Kong Med J"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.2147\/CEG.S154235"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(92)70519-7"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12262-012-0755-6"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/tmi.12908"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-147-9-200711060-00021"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000001625"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1309\/DKKECWQWMG4J23E3"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000001162"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(16)31889-3"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12664-014-0467-x"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.14.741"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v12.i39.6371"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-015-2208-8"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izy154"}],"container-title":["Tropical Medicine &amp; International Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftmi.13169","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tmi.13169","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T00:41:32Z","timestamp":1694652092000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tmi.13169"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,8]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["10.1111\/tmi.13169"],"URL":"https:\/\/doi.org\/10.1111\/tmi.13169","archive":["Portico"],"relation":{},"ISSN":["1360-2276","1365-3156"],"issn-type":[{"value":"1360-2276","type":"print"},{"value":"1365-3156","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,8]]},"assertion":[{"value":"2018-11-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}