{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T10:47:26Z","timestamp":1694774846825},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,11,29]],"date-time":"2018-11-29T00:00:00Z","timestamp":1543449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the frequency of therapeutic failure among patients with acute and subacute brucellosis and to explore the predictors of failure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study included 213 consecutive, na\u00efve patients with acute and subacute brucellosis. All participants underwent clinical evaluation, chest radiography, stool microscopic examination and interferon\u2010gamma release assay. Patients received the WHO\u2010recommended therapy of doxycycline 200 mg\/day and rifampin 900 mg\/day, for 6 weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean age of the study population was 39.8 \u00b1 12.2 years; 64.8% of them were males. The therapeutic failure rate was 16.4%. Adverse effects were reported by 13.1%. Multivariate analysis of factors associated with therapeutic failure revealed latent tuberculosis infection (LTBI) (OR 3.1, 95% CI, 1.9\u201324.6, <jats:italic>P<\/jats:italic>: 0.009), ascariasis (OR 2.6, 95% CI 1.5\u201317.9, <jats:italic>P<\/jats:italic>: 0.012), and the use of acid suppressive therapy (OR 2.1, 95% CI 1.2\u201319.5, <jats:italic>P<\/jats:italic>: 0.037) as the predictors of therapeutic failure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The prevalence of therapeutic failure among the Egyptian patients with acute\/subacute brucellosis is increasing. Predictors of therapeutic failure are LTBI, ascariasis, and the use of acid suppressive therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.13179","type":"journal-article","created":{"date-parts":[[2018,11,9]],"date-time":"2018-11-09T11:30:09Z","timestamp":1541763009000},"page":"185-191","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Predictors of therapeutic failure among patients with acute brucellosis treated by dual therapy with doxycycline\u2010rifampin"],"prefix":"10.1111","volume":"24","author":[{"given":"Ahmad Farooq","family":"Alsayed Hasanain","sequence":"first","affiliation":[{"name":"Department of Tropical Medicine and Gastroenterology Faculty of Medicine Assiut University Assiut Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad Abbas","family":"El\u2010Masry","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Faculty of Medicine Assiut University Assiut Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali Abdel\u2010Azeem Hasan","family":"Zayed","sequence":"additional","affiliation":[{"name":"Department of Chest Diseases Faculty of Medicine Assiut University Assiut Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amany Mohamed Adawi","family":"Nafee","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology Faculty of Medicine Assiut University Assiut Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rasha Abdel\u2010Monem Hassan","family":"Attia","sequence":"additional","affiliation":[{"name":"Department of Parasitology Faculty of Medicine Assiut University Assiut Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sherif Mohamed","family":"Abdel\u2010Aal","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology Faculty of Medicine Assiut University Assiut Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,11,29]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0034925"},{"key":"e_1_2_5_3_1","first-page":"233","article-title":"Brucellosis in humans\u2013etiology, diagnostics, clinical forms","volume":"20","author":"Gali\u0144ska EM","year":"2013","journal-title":"Ann Agric Environ Med"},{"key":"e_1_2_5_4_1","first-page":"49","article-title":"Seroepidemiological study on human brucellosis in Assiut Governorate","volume":"12","author":"Hussein AA","year":"2005","journal-title":"Egypt J Immunol"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1135(02)00248-1"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1412.071452"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2015.03.003"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(06)70382-6"},{"key":"e_1_2_5_9_1","unstructured":"Centers for Disease Control and Prevetion. 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