{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:03:34Z","timestamp":1787166214962,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,7,31]],"date-time":"2019-07-31T00:00:00Z","timestamp":1564531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2019,9]]},"abstract":"Abstract<\/jats:title>\n \n Objective<\/jats:title>\n \n To estimate the cost\u2010effectiveness of strategies for the treatment of\n VL<\/jats:styled-content>\n in Brazil.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Cost\u2010effectiveness study comparing three therapeutic options: meglumine antimoniate (\n MA<\/jats:styled-content>\n ), liposomal amphotericin B (\n LAMB<\/jats:styled-content>\n ) and a combination of\n LAMB<\/jats:styled-content>\n plus\n MA<\/jats:styled-content>\n (\n LAMB<\/jats:styled-content>\n plus\n MA<\/jats:styled-content>\n ), from public health system and societal perspectives. An analytical decision\u2010making model was used to compare strategies for the following outcomes: early therapeutic failure avoided at 30\u00a0days, days of hospitalisation avoided and\n VL<\/jats:styled-content>\n cure at 180\u00a0days. The efficacy and safety parameters of the drugs came from a randomised, open\u2010label trial and the cost data came from a cost\u2010of\u2010illness study, both carried out in Brazil.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n For all outcomes analysed, the\n LAMB<\/jats:styled-content>\n strategy was more effective. The\n MA<\/jats:styled-content>\n strategy was inferior to the\n LAMB<\/jats:styled-content>\n plus\n MA<\/jats:styled-content>\n strategy for the outcomes early therapeutic failure avoided and cure. When only\n LAMB<\/jats:styled-content>\n and\n MA<\/jats:styled-content>\n were compared from a societal perspective, a cost of US$ 278.56 was estimated for each additional early therapeutic failure avoided, a cost of US$ 26.88 for each additional day of hospitalisation avoided and a cost of\n US<\/jats:styled-content>\n $ 89.88 for each additional case of cured\n VL<\/jats:styled-content>\n , for the\n LAMB<\/jats:styled-content>\n strategy\n vs<\/jats:italic>\n .\n MA<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n In Brazil, the\n LAMB<\/jats:styled-content>\n strategy proved to be cost\u2010effective for treating\n VL<\/jats:styled-content>\n , considering a\n GDP<\/jats:styled-content>\n per capita as the willingness\u2010to\u2010pay threshold, for all of the outcomes analysed in comparison to\n MA<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/tmi.13284","type":"journal-article","created":{"date-parts":[[2019,7,6]],"date-time":"2019-07-06T07:29:53Z","timestamp":1562398193000},"page":"1064-1077","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Treatment for human visceral leishmaniasis: a cost\u2010effectiveness analysis for Brazil"],"prefix":"10.1111","volume":"24","author":[{"given":"Isis Polianna Silva Ferreira","family":"de Carvalho","sequence":"first","affiliation":[{"name":"Centre for Tropical Medicine University of Brasilia Brasilia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry Maia","family":"Peixoto","sequence":"additional","affiliation":[{"name":"Centre for Tropical Medicine University of Brasilia Brasilia Brazil"},{"name":"National Institute for Science and Technology for Health Technology Assessment Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo Adolfo Sierra","family":"Romero","sequence":"additional","affiliation":[{"name":"Centre for Tropical Medicine University of Brasilia Brasilia Brazil"},{"name":"National Institute for Science and Technology for Health Technology Assessment Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Regina Fernandes","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Centre for Tropical Medicine University of Brasilia Brasilia Brazil"},{"name":"National Institute for Science and Technology for Health Technology Assessment Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,7,31]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035671"},{"key":"e_1_2_5_3_1","unstructured":"WHO.Leishmaniasis. 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