{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T10:38:41Z","timestamp":1789987121144,"version":"4.0.1"},"reference-count":42,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,8,19]],"date-time":"2019-08-19T00:00:00Z","timestamp":1566172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To review the diagnostic test accuracy and predictive value of statistical models in differentiating the severity of dengue infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Electronic searches were conducted in the Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, <jats:styled-content style=\"fixed-case\">MEDLINE<\/jats:styled-content> (complete), PubMed and Scopus. Eligible studies to be included in this review were cohort studies with participants confirmed by laboratory test for dengue infection and comparison among the different severity of dengue infection by using statistical models. The methodological quality of the paper was assessed by independent reviewers using <jats:styled-content style=\"fixed-case\">QUADAS<\/jats:styled-content>\u20102.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010six studies published from 1994 to 2017 were included. Most diagnostic models produced an accuracy of 75% to 80% except one with 86%. Two models predicting severe dengue according to the <jats:styled-content style=\"fixed-case\">WHO<\/jats:styled-content> 2009 classification have 86% accuracy. Both of these logistic regression models were applied during the first three days of illness, and their sensitivity and specificity were 91\u2013100% and 79.3\u201386%, respectively. Another model which evaluated the 30\u2010day mortality of dengue infection had an accuracy of 98.5%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although there are several potential predictive or diagnostic models for dengue infection, their limitations could affect their validity. It is recommended that these models be revalidated in other clinical settings and their methods be improved and standardised in future.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.13294","type":"journal-article","created":{"date-parts":[[2019,8,2]],"date-time":"2019-08-02T10:48:21Z","timestamp":1564742901000},"page":"1169-1197","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Diagnostic accuracy and predictive value in differentiating the severity of dengue infection"],"prefix":"10.1111","volume":"24","author":[{"given":"Gary Kim Kuan","family":"Low","sequence":"first","affiliation":[{"name":"Department of Public Health Torrens University Pyrmont NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jackob","family":"Kagize","sequence":"additional","affiliation":[{"name":"Department of Public Health Torrens University Pyrmont NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine J.","family":"Faull","sequence":"additional","affiliation":[{"name":"Department of Public Health Torrens University Adelaide SA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aizad","family":"Azahar","sequence":"additional","affiliation":[{"name":"Anaesthesiology Unit Universiti Putra Malaysia Serdang Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,8,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12060"},{"key":"e_1_2_7_3_1","unstructured":"World Health Organization.Dengue and severe dengue[Internet]. 13 Sept 2018. 2018. 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