{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T23:39:29Z","timestamp":1785368369946,"version":"3.55.0"},"reference-count":27,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,9,30]],"date-time":"2019-09-30T00:00:00Z","timestamp":1569801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Human T\u2010cell lymphotropic virus type 1 (HTLV\u20101), the causative agent of adult T\u2010cell leukaemia\/lymphoma (ATL) and HTLV\u20101\u2010associated myelopathy\/tropical spastic paraparesis (HAM\/TSP), is endemic in sub\u2010Saharan Africa (SSA) and poses a high morbidity and mortality risk. Its prevalence in the general population is poorly understood. The potential for prevention motivated us to do a systematic review and meta\u2010analysis of population\u2010based studies to estimate the prevalence of HTLV\u20101 in SSA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A comprehensive, no\u2010limit search was conducted in EMBASE, PubMed, Web of Science and the Cochrane Library from their inception dates to March 2019. Population\u2010based studies presenting data on HTLV\u20101 in sub\u2010Saharan Africa were included. Pooled prevalence was estimated using a random\u2010effects meta\u2010analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 21 studies were included, representing 42\u00a0297 participants. The pooled HTLV\u20101 seroprevalence was 3.19% (95% CI 2.36\u20134.12%) with variations across year of study. Prevalence of HTLV\u20101 positively correlated with year of study (\u03b2\u00a0=\u00a00.0036, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.007). Participants from Central, Western and Southern Africa had a seroprevalence of 4.16% (95% CI 2.43\u20136.31%), 2.66% (95% CI 1.80\u20133.68%) and 1.56% (95% CI 0.48\u20133.15%), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings suggest that HTLV\u20101 infection is a public health concern in SSA and highlight the need to implement effective preventive programmes and interventions aimed at reducing the burden of this common yet neglected infection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.13305","type":"journal-article","created":{"date-parts":[[2019,8,29]],"date-time":"2019-08-29T18:00:30Z","timestamp":1567101630000},"page":"1277-1290","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Population\u2010based prevalence of human T\u2010lymphotropic virus type 1 in sub\u2010Saharan Africa: a systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"24","author":[{"given":"Alain M.","family":"Ngoma","sequence":"first","affiliation":[{"name":"Douglas Hospital Research Centre McGill University Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magot D.","family":"Omokoko","sequence":"additional","affiliation":[{"name":"H\u00f4pital de la Cit\u00e9\u2010de\u2010la\u2010Sant\u00e9 affiliated to the University of Montreal Laval QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulin B.","family":"Mutombo","sequence":"additional","affiliation":[{"name":"School of Public Health University of Kinshasa Kinshasa Democratic Republic of the Congo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eddy S.","family":"Mvika","sequence":"additional","affiliation":[{"name":"Centre National de Transfusion Sanguine Kinshasa Democratic Republic of the Congo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremie M.","family":"Muwonga","sequence":"additional","affiliation":[{"name":"Laboratoire National de R\u00e9f\u00e9rence du Sida University of Kinshasa Kinshasa Democratic Republic of the Congo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth E.","family":"Nollet","sequence":"additional","affiliation":[{"name":"Department of Blood Transfusion and Transplantation Immunology Fukushima Medical University Fukushima Japan"},{"name":"Radiation Medical Science Center Fukushima Medical University Fukushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Ohto","sequence":"additional","affiliation":[{"name":"Department of Blood Transfusion and Transplantation Immunology Fukushima Medical University Fukushima Japan"},{"name":"Radiation Medical Science Center Fukushima Medical University Fukushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,9,30]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2012.00388"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.01425"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2012.00322"},{"key":"e_1_2_5_5_1","first-page":"8","article-title":"Mother\u2010to\u2010child transmission of HTLV\u20101 epidemiological aspects, mechanisms and determinants of mother\u2010to\u2010child transmission","volume":"3","author":"Percher F","year":"2016","journal-title":"Viruses"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.15234"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-117-11-933"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1086\/423957"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1208968"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00063-09"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199202063260604"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-111-7-555"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910510609"},{"key":"e_1_2_5_14_1","doi-asserted-by":"crossref","first-page":"4049","DOI":"10.1128\/JCM.38.11.4049-4057.2000","article-title":"Human T\u2010cell lymphotropic virus type 1 gag indeterminate western blot patterns in Central Africa: relationship to Plasmodium falciparum infection","volume":"38","author":"Mahieux R","year":"2000","journal-title":"J Clin Microbiol"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781444300161.ch12"},{"key":"e_1_2_5_16_1","unstructured":"SchwarzerG.Meta: Meta\u2010Analysis with R. 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