{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T18:40:17Z","timestamp":1788460817128,"version":"build-2803163510"},"reference-count":44,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,10,7]],"date-time":"2019-10-07T00:00:00Z","timestamp":1570406400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To describe the occurrence of both peripheral and central auditory system dysfunction in sickle cell anaemia (<jats:styled-content style=\"fixed-case\">SCA<\/jats:styled-content>) patients and discuss the different mechanisms hypothesised to be responsible for these alterations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An electronic search was conducted using PubMed Central<jats:sup>\u00ae<\/jats:sup> (<jats:styled-content style=\"fixed-case\">MEDLINE<\/jats:styled-content>), <jats:styled-content style=\"fixed-case\">LILACS<\/jats:styled-content><jats:sup>\u00ae<\/jats:sup> and Scopus<jats:sup>\u00ae<\/jats:sup> databases. This systematic review was performed in accordance with the <jats:styled-content style=\"fixed-case\">PRISMA<\/jats:styled-content> statement. Original observational studies that utilised audiological tests for auditory system evaluations in <jats:styled-content style=\"fixed-case\">SCA<\/jats:styled-content> were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 183 records were found in the databases searched. Twenty\u2010one of these studies met the inclusion criteria. Pooled prevalence of sensorineural hearing loss (<jats:styled-content style=\"fixed-case\">SNHL<\/jats:styled-content>) was 20.5% (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 10.3\u201333%). Retrocochlear involvement was detected with the auditory brainstem response, which assesses integrity of the cochlea, 8th cranial nerve and brainstem structures. In addition, the increase in otoacoustic emission amplitudes in <jats:styled-content style=\"fixed-case\">SCA<\/jats:styled-content> patients indicates changes in cochlear micromechanics and precedes the expression of a detectable cochlear pathology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The prevalence of the <jats:styled-content style=\"fixed-case\">SNHL<\/jats:styled-content> is higher than in the general population. Dysfunction of the auditory system may be present in <jats:styled-content style=\"fixed-case\">SCA<\/jats:styled-content> patients, with the most probable mechanism being the presence of circulatory disturbances resulting from the chronic inflammatory state of the disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.13307","type":"journal-article","created":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T08:48:35Z","timestamp":1567932515000},"page":"1264-1276","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Dysfunction of the auditory system in sickle cell anaemia: a systematic review with meta\u2010analysis"],"prefix":"10.1111","volume":"24","author":[{"given":"Mara Renata","family":"Rissatto - Lago","sequence":"first","affiliation":[{"name":"Postgraduate Course in Medicine and Human Health Bahiana School of Medicine and Public Health Salvador Brazil"},{"name":"College of Speech Therapy State University of 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